ID   A0A2R9CEX0_PANPA        Unreviewed;       486 AA.
AC   A0A2R9CEX0;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Glycerophosphodiester phosphodiesterase domain containing 5 {ECO:0000313|Ensembl:ENSPPAP00000039558.1};
GN   Name=GDPD5 {ECO:0000313|Ensembl:ENSPPAP00000039558.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000039558.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000039558.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000039558.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase
CC       family. {ECO:0000256|ARBA:ARBA00007277}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJFE02047994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02047995; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9CEX0; -.
DR   Ensembl; ENSPPAT00000062469.1; ENSPPAP00000039558.1; ENSPPAG00000042473.1.
DR   GeneTree; ENSGT00940000159690; -.
DR   Proteomes; UP000240080; Chromosome 11.
DR   Bgee; ENSPPAG00000042473; Expressed in placenta and 6 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   CDD; cd08608; GDPD_GDE2; 1.
DR   Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR   InterPro; IPR030395; GP_PDE_dom.
DR   InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR   PANTHER; PTHR23344:SF6; GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE DOMAIN-CONTAINING PROTEIN 5; 1.
DR   PANTHER; PTHR23344; GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE; 1.
DR   Pfam; PF03009; GDPD; 1.
DR   Pfam; PF13653; GDPD_2; 1.
DR   SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR   PROSITE; PS51704; GP_PDE; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        44..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        74..94
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          109..366
FT                   /note="GP-PDE"
FT                   /evidence="ECO:0000259|PROSITE:PS51704"
FT   REGION          462..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  54586 MW;  D4150C685E68CB7E CRC64;
     MVRHQPLQYY EPQLCLSCLT GIYGCRWKRY QRSHDDTTPG TAPFLHVGAL AAVTMLSWIV
     AGQFARAERT SSQVTILCTF FTVVFALYLA PLTISSPCIM EKKDLGPKPA LIGHRGAPML
     APEHTLMSFR KALEQKLYGL QADITISLDG VPFLMHDTTL RRTTNVEEEF PELARRPASM
     LNWTTLQRLN AGQWFLKTDP FWTASSLSPS DHREAQNQSI CSLAELLELA KGNATLLLNL
     RDPPREHPYR SSFINVTLEA VLHSGFPQHQ VMWLPSRQRP LVRKVAPGFQ QTSGSKEAVA
     SLRRGHIQRL NLRYTQVSRQ ELRDYASWNL SVNLYTVNAP WLFSLLWCAG VPSVTSDNSH
     TLSQVPSPLW IMPPDEYCLM WVTADLVSFT LIVGIFVLQK WRLGGIRSYN PEQIMLSAAV
     RRTSRDVSIM KEKLIFSEIS DGVEVSDVLS VCSDNSYDTY ANSTATPVGP RGGGSRTKTL
     IERSGR
//