ID A0A2R9CFX3_PANPA Unreviewed; 1459 AA.
AC A0A2R9CFX3;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN Name=POLA1 {ECO:0000313|Ensembl:ENSPPAP00000040799.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000040799.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000040799.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000040799.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|RuleBase:RU000442};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR EMBL; AJFE02067103; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067106; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02067108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSPPAT00000063718.1; ENSPPAP00000040799.1; ENSPPAG00000042971.1.
DR GeneTree; ENSGT00550000074891; -.
DR Proteomes; UP000240080; Chromosome X.
DR Bgee; ENSPPAG00000042971; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0031981; C:nuclear lumen; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:UniProt.
DR GO; GO:1902975; P:mitotic DNA replication initiation; IEA:InterPro.
DR CDD; cd05776; DNA_polB_alpha_exo; 1.
DR CDD; cd05532; POLBc_alpha; 1.
DR Gene3D; 2.40.50.730; -; 1.
DR Gene3D; 3.30.70.2820; -; 1.
DR Gene3D; 1.10.3200.20; DNA Polymerase alpha, zinc finger; 1.
DR Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR024647; DNA_pol_a_cat_su_N.
DR InterPro; IPR042087; DNA_pol_B_thumb.
DR InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR InterPro; IPR038256; Pol_alpha_znc_sf.
DR InterPro; IPR045846; POLBc_alpha.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR015088; Znf_DNA-dir_DNA_pol_B_alpha.
DR NCBIfam; TIGR00592; pol2; 1.
DR PANTHER; PTHR45861; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR PANTHER; PTHR45861:SF1; DNA POLYMERASE ALPHA CATALYTIC SUBUNIT; 1.
DR Pfam; PF12254; DNA_pol_alpha_N; 1.
DR Pfam; PF00136; DNA_pol_B; 1.
DR Pfam; PF03104; DNA_pol_B_exo1; 1.
DR Pfam; PF08996; zf-DNA_Pol; 1.
DR PRINTS; PR00106; DNAPOLB.
DR SMART; SM00486; POLBc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF90234; Zinc finger domain of DNA polymerase-alpha; 1.
DR PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|RuleBase:RU000442};
KW DNA-binding {ECO:0000256|RuleBase:RU000442};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|RuleBase:RU000442};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU000442};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1459
FT /note="DNA polymerase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015354800"
FT DOMAIN 43..104
FT /note="DNA polymerase alpha catalytic subunit N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12254"
FT DOMAIN 418..718
FT /note="DNA-directed DNA polymerase family B exonuclease"
FT /evidence="ECO:0000259|Pfam:PF03104"
FT DOMAIN 991..1224
FT /note="DNA-directed DNA polymerase family B
FT multifunctional"
FT /evidence="ECO:0000259|Pfam:PF00136"
FT DOMAIN 1263..1452
FT /note="Zinc finger DNA-directed DNA polymerase family B
FT alpha"
FT /evidence="ECO:0000259|Pfam:PF08996"
FT REGION 107..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1459 AA; 165658 MW; 0C7ABC06D1B1F93A CRC64;
MADNFVTSLV NFFLFSALSD SGSFVSSRAR REKKSKKGRQ EALERLKKAK AGEKYKYEVE
DFTGVYEEVD EEQYSKLVQA RQDDDWIVDD DGIGYVEDGR EIFDDDLEDD ALDADEKGKD
GKARNKDKRN VKKLAVTKPN NIKSMFIACA GKKTADKAVD LSKDDLLGDI LQDLNTETPQ
ITPPPVMILK KKRSIGASPN PFSVHTATAV PSGKIASPVS RKEPPLTPVP LKRAEFAGDD
VQVESTEEEQ ESGAMEFEDG DFDEPMEVEE VDLEPMAAKA WDQESEPAEE VKQEADSGKG
TMSYLGSFLP DVSCWDIDQE GDSSFSVQEV QVDSSHLPLV KGADEEQVFH FYWLDAYEDQ
YNQPGVVFLF GKVWIESAET HVSCCVMVKN IERTLYFLPR EMKIDLNTGK ETGTPISMKD
VYEEFDEKIA TKYKIMKFKS KPVEKNYAFE IPDVPEKSEY LEVKYSAEMP QLPQDLKGET
FSHVFGTNTS SLELFLMNRK IKGPCWLEVK SPQLLNQPVS WCKVEAMALK PDLVNVIKDV
SPPPLVVMAF SMKTMQNAKN HQNEIIAMAA LVHHSFALDK AAPKPPFQSH FCVVSKPKDC
IFPYAFKEVI EKKNVKVEVA ATERTLLGFF LAKVHKIDPD IIVGHNIYGF ELEVLLQRIN
VCKAPHWSKI GRLKRSNMPK LGGRSGFGER NATCGRMICD VEISAKELIR CKSYHLSELV
QQILKTERVV IPMENIQNMY SESSQLLYLL EHTWKDAKFI LQIMCELNVL PLALQITNIA
GNIMSRTLMG GRSERNEFLL LHAFYENNYI VPDKQIFRKP QQKLGDEDEE IDGDTNKYKK
GRKKAAYAGG LVLDPKVGFY DKFILLLDFN SLYPSIIQEF NICFTTVQRV ASEAQKVTED
GEQEQIPELP DPSLEMGILP REIRKLVERR KQVKQLMKQQ DLNPDLILQY DIRQKALKLT
ANSMYGCLGF SYSRFYAKPL AALVTYKGRE MNLEVIYGDT DSIMINTNST NLEEVFKLGN
KVKSEVNKLY KLLEIDIDGV FKSLLLLKKK KYAALVVEPT SDGNYVTKQE LKGLDIVRRD
WCDLAKDTGN FVIGQILSDQ SRDTIVENIQ KRLIEIGENV LNGSVPVSQF EINKALTKDP
QDYPDKKSLP HVHVALWINS QGGRKVKAGD TVSYVICQDG SNLTASQRAY APEQLQKQDN
LTIDTQYYLA QQIHPVVARI CEPIDGIDAV LIATWLGLDP TQFRVHHYHK DEENDALLGG
PAQLTDEEKY RDCERFKCPC PTCGTENIYD NVFDGSGTDM EPSLYRCSNI DCKASPLTFT
VQLSNKLIMD IRRFIKKYYD GWLICEEPTC RNRTRHLPLQ FSRTGPLCPA CMKATLQPEY
SDKSLYTQLC FYRYIFDAEC ALEKLTTDHE KDKLKKQFFT PKVLQDYRKL KNTAEQFLSR
SGYSEVNLSK LFAGCAVKS
//
