ID A0A2R9CGB8_PANPA Unreviewed; 1314 AA.
AC A0A2R9CGB8;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Protein phosphatase 1 regulatory subunit 9A {ECO:0000313|Ensembl:ENSPPAP00000037242.1};
GN Name=PPP1R9A {ECO:0000313|Ensembl:ENSPPAP00000037242.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000037242.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000037242.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000037242.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; AJFE02030127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030128; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030129; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030131; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02030135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008960232.1; XM_008961984.1.
DR Ensembl; ENSPPAT00000060141.1; ENSPPAP00000037242.1; ENSPPAG00000041301.1.
DR GeneTree; ENSGT00940000155538; -.
DR OrthoDB; 2911512at2759; -.
DR Proteomes; UP000240080; Chromosome 7.
DR Bgee; ENSPPAG00000041301; Expressed in prefrontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd09512; SAM_Neurabin-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR040645; Neurabin-1/2_PDZ.
DR InterPro; IPR043446; Neurabin-like.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR16154; NEURABIN; 1.
DR PANTHER; PTHR16154:SF22; NEURABIN-1; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17817; PDZ_5; 1.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080}.
FT DOMAIN 504..592
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1204..1267
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 413..432
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 839..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..961
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 975..1034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1120..1173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1268..1314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 600..627
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 680..777
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..53
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..170
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 279..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..645
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 851..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..961
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1027
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1120..1163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1268..1303
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1314 AA; 147185 MW; E8C43DB8F5CD9018 CRC64;
MLKTESSGER TTLRSASPHR NAYRTEFQAL KSTFDKPKSD GEQKTKEGEG SQQSRGRKYG
SNVNRIKNLF MQMGMEPNEN AAVIAKTRGK GGHSSPQRRM KPKEFLEKTD GSVVKLESSV
SERISRFDTM YDGPSYSKFT ETRKMFERSV HESGQNNRYS PKKEKAGGSE PQDEWGGSKS
NRGSTDSLDS LSSRTEAVSP TVSQLSAVFE NTDSPSAIIS EKAENNEYSV TGHYPLNLPS
VTVTNLDTFG HLKDSNSWPP SNKQGVDTED AHKSNATPVP EVASKSTSLA SIPGEEIQQS
KEPEDSTSNQ QTPDSIDKDG PEEPCAESKA MPKSEIPSPQ SQLLEDAEAN LVGSEAAKQQ
RKELAGGDFT SPDASASSCG KEVPEDSNNF DGSHVYMHSD YNVYRVRSRY NSDWGETGTE
QDEEEDSDEN SYYQPDMEYS EIVGLPEEEE IPANRKIKFS SAPIKVFNTY SNEDYDRRND
EVDPVAASAE YELEKRVEKL ELFPVELEKD EDGLGISIIG MGVGADAGLE KLGIFVKTVT
EGGAAQRDGR IQVNDQIVEV DGISLVGVTQ NFAATVLRNT KGNVRFVIGR EKPGQVSEVA
QLISQTLEQE RRQRELLEQH YAQYDADDDE TGEYATDEEE DEVGPVLPGS DMAIEVFELP
ENEDMFSPSE LDTSKLSHKF KELQIKHAVT EAEIQKLKTK LQAAENEKVR WELEKTQLQQ
NIEENKERML KLESYWIEAQ TLCHTVNEHL KETQSQYQAL EKKYNKAKKL IKDFQQKELD
FIKRQEAERK KIEDLEKAHL VEVQGLQVRI RDLEAEVFRL LKQNGTQVNN NNNIFERRTS
LGEVSKGDTM ENLDGKQTSC QDGLSQDLNE AVPETERLDS KALKTRAQLS VKNRRQRPSR
TRLYDSVSST DGEDSLERKP SNSFYNHMHI TKLLPPKGLR TSSPESDSGV PPLTPVDSNV
PFSSDHIAEF QEEPLDPEMG PLSSMWGDTS LFSTSKSDHD VEESPCHHQT TNKKILQEKD
DAKDPKSLRA SSSLAVQGGK IKRKFVDLGA PLRRNSNKGK KWKEKEKEAS RFSAGSRIFR
GRLENWTPKP CSTAQTSTRS PCMPFSWFND SRKGSYSFRN LPAPTSSLQP SPETLISDKK
GSKNFTFNDD FSPSSTSSAD LSGLGAEPKT PGLSQSLALS SDEILDDGQS PKHSQCQNRA
VQEWSVQQVS HWLMSLNLEQ YVSEFSAQNI TGEQLLQLDG NKLKALGMTA SQDRAVVKKK
LKEMKMSLEK ARKAQEKMEK QREKLRRKEQ EQMQRKSKKT EKMTSTTAEG AGEQ
//
