ID   A0A2R9CHI5_PANPA        Unreviewed;       539 AA.
AC   A0A2R9CHI5;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=SHC adaptor protein 2 {ECO:0008006|Google:ProtNLM};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000041374.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000041374.1, ECO:0000313|Proteomes:UP000240080}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22722832; DOI=10.1038/nature11128;
RA   Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA   Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA   Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA   Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA   Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA   Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA   Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA   Paabo S.;
RT   "The bonobo genome compared with the chimpanzee and human genomes.";
RL   Nature 486:527-531(2012).
RN   [2] {ECO:0000313|Ensembl:ENSPPAP00000041374.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AJFE02074505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02074506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02074507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02074508; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02074509; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02074510; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9CHI5; -.
DR   STRING; 9597.ENSPPAP00000041374; -.
DR   Ensembl; ENSPPAT00000064300.1; ENSPPAP00000041374.1; ENSPPAG00000043298.1.
DR   GeneTree; ENSGT00950000182870; -.
DR   OMA; MSISVHI; -.
DR   Proteomes; UP000240080; Chromosome 19.
DR   Bgee; ENSPPAG00000043298; Expressed in liver and 6 other cell types or tissues.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd01209; PTB_Shc; 1.
DR   CDD; cd09925; SH2_SHC; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR006019; PID_Shc-like.
DR   InterPro; IPR006020; PTB/PI_dom.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR035676; SHC_SH2.
DR   PANTHER; PTHR10337; SHC TRANSFORMING PROTEIN; 1.
DR   PANTHER; PTHR10337:SF5; SHC-TRANSFORMING PROTEIN 2; 1.
DR   Pfam; PF00640; PID; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   PRINTS; PR00629; SHCPIDOMAIN.
DR   SMART; SM00462; PTB; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS01179; PID; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          113..286
FT                   /note="PID"
FT                   /evidence="ECO:0000259|PROSITE:PS01179"
FT   DOMAIN          444..535
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          26..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          417..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  59119 MW;  1161F211E2F4744C CRC64;
     SCRGPQRVCP PPPPCTRVSA AQPEWAMWNE NPSPYGPAAP DTGTDIIPEA HALPERRQPL
     SSQHPTKAAP EPPGTEERAR PQGWWRRRRA AGKRDVAPLR GFRWHLTPVL SPQYMGCIEV
     LRSMRSLDFN TRTQVTREAI NRLHEAVPGV RGSWKKKAPN KALASVLGKS NLRFAGMSIS
     IHISTDGLSL SVPATRQVIA NHHMPSISFA SGGDTDMTDY VAYVAKDPIN QRACHILECC
     EGLAQSIIST VGQAFELRFK QYLHSPPKVA LPPERLAGPE ESAWGDEEDS LEHNYYNSIP
     GKEPPLGGLV DSRLALTQPC ALTALDQGPS PSLRDACSLP WDVGSTGTAP PGDGYVQADA
     RGPPGHEEHL YVNTQGLDAP EPEDSPKKDL FDMRPFEDAL KLHECSVAAG VTAAPLPLED
     QWPSPPTRRA PVAPTEEQLR QEPWYHGRMS RRAAERMLRA DGDFLVRDSV TNPGQYVLTG
     MHAGQPKHLL LVDPEGVVRT KDVLFESISH LIDHHLQNGQ PIVAAESELH LRGVVSREP
//