ID A0A2R9CJ95_PANPA Unreviewed; 248 AA.
AC A0A2R9CJ95;
DT 20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT 20-JUN-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=IgG receptor FcRn large subunit p51 {ECO:0000256|ARBA:ARBA00040486};
DE AltName: Full=IgG Fc fragment receptor transporter alpha chain {ECO:0000256|ARBA:ARBA00041407};
DE AltName: Full=Neonatal Fc receptor {ECO:0000256|ARBA:ARBA00041280};
GN Name=FCGRT {ECO:0000313|Ensembl:ENSPPAP00000042025.1};
OS Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000042025.1, ECO:0000313|Proteomes:UP000240080};
RN [1] {ECO:0000313|Ensembl:ENSPPAP00000042025.1, ECO:0000313|Proteomes:UP000240080}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22722832; DOI=10.1038/nature11128;
RA Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
RA Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
RA Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
RA Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
RA Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
RA Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
RA Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
RA Paabo S.;
RT "The bonobo genome compared with the chimpanzee and human genomes.";
RL Nature 486:527-531(2012).
RN [2] {ECO:0000313|Ensembl:ENSPPAP00000042025.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC {ECO:0000256|ARBA:ARBA00008637}.
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DR EMBL; AJFE02046107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046112; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJFE02046113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2R9CJ95; -.
DR Ensembl; ENSPPAT00000064954.1; ENSPPAP00000042025.1; ENSPPAG00000043605.1.
DR GeneTree; ENSGT01100000263475; -.
DR Proteomes; UP000240080; Chromosome 19.
DR Bgee; ENSPPAG00000043605; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR CDD; cd21011; IgC1_MHC-like_FcRn; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR PANTHER; PTHR16675:SF3; IGG RECEPTOR FCRN LARGE SUBUNIT P51; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..204
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 85..172
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 248 AA; 26685 MW; 8267767C7FC0670D CRC64;
SHLSLLYHLT AVSSPAPGTP AFWVSGWLGP QQYLSYNSLR GEAEPCGAWV WENQVSWYWE
KETTDLRIKE KLFLEAFKAL GGKEPPSMRL KARPSSPGFS VLTCSAFSFY PPELQLRFLR
NGLAAGTGQG DFGPNSDGSF HASSSLTVKS GDEHHYCCIV QHAGLAQPLR VELESPAKSS
VLVVGIVIGV LLLTAAAVGG ALLWRRMRSG LPAPWISLRG DDTGVLLPTP GEAQDADLKD
VNVIPATA
//
