ID   A0A2R9CK60_PANPA        Unreviewed;       261 AA.
AC   A0A2R9CK60;
DT   20-JUN-2018, integrated into UniProtKB/TrEMBL.
DT   20-JUN-2018, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protein activator of interferon induced protein kinase EIF2AK2 {ECO:0000313|Ensembl:ENSPPAP00000041383.1};
GN   Name=PRKRA {ECO:0000313|Ensembl:ENSPPAP00000041383.1};
OS   Pan paniscus (Pygmy chimpanzee) (Bonobo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000041383.1, ECO:0000313|Proteomes:UP000240080};
RN   [1] {ECO:0000313|Ensembl:ENSPPAP00000041383.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PRKRA family.
CC       {ECO:0000256|ARBA:ARBA00005856}.
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DR   EMBL; AJFE02051677; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AJFE02051678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2R9CK60; -.
DR   STRING; 9597.ENSPPAP00000041383; -.
DR   Ensembl; ENSPPAT00000064309.1; ENSPPAP00000041383.1; ENSPPAG00000043306.1.
DR   GeneTree; ENSGT00940000157618; -.
DR   OMA; HRKEFTI; -.
DR   Proteomes; UP000240080; Unplaced.
DR   Bgee; ENSPPAG00000043306; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0070578; C:RISC-loading complex; IEA:Ensembl.
DR   GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0070883; F:pre-miRNA binding; IEA:Ensembl.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IEA:Ensembl.
DR   GO; GO:0042474; P:middle ear morphogenesis; IEA:Ensembl.
DR   GO; GO:0042473; P:outer ear morphogenesis; IEA:Ensembl.
DR   GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IEA:Ensembl.
DR   GO; GO:0031054; P:pre-miRNA processing; IEA:Ensembl.
DR   GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR   GO; GO:0070922; P:RISC complex assembly; IEA:Ensembl.
DR   GO; GO:0030422; P:siRNA processing; IEA:Ensembl.
DR   GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR   CDD; cd19889; DSRM_PRKRA_rpt1; 1.
DR   CDD; cd19891; DSRM_PRKRA_rpt2; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR044465; PRKRA_DSRM_1.
DR   InterPro; IPR044466; PRKRA_DSRM_2.
DR   PANTHER; PTHR46205:SF2; INTERFERON-INDUCIBLE DOUBLE-STRANDED RNA-DEPENDENT PROTEIN KINASE ACTIVATOR A; 1.
DR   PANTHER; PTHR46205; LOQUACIOUS, ISOFORM B; 1.
DR   Pfam; PF00035; dsrm; 2.
DR   SMART; SM00358; DSRM; 2.
DR   SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR   PROSITE; PS50137; DS_RBD; 2.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000240080};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN          34..101
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
FT   DOMAIN          126..194
FT                   /note="DRBM"
FT                   /evidence="ECO:0000259|PROSITE:PS50137"
SQ   SEQUENCE   261 AA;  28944 MW;  E1E81609E3D7B29C CRC64;
     MSQSRHRAEA PPLEREDSGT FSLGKMITAK PGKTPIQVLH EYGMKTKNIP VYECERSDVQ
     IHVPTFTFRV TVGDITCTGE GTSKKLAKHR AAEAAINILK ANASICFAVP DPLMPDPSKQ
     PKNQLNPIGS LQELAIHHGW RLPEYTLSQE GGPAHKREYT TICRLESFME TGKGASKKQA
     KRNAAEKFLA KFSNISPENH ISLTNVVGHS LGCTWHSLRN SPGEKINLLK RSLLSIPNTD
     YIQLLSEIAK EQGFNITYLD I
//