ID   A0A2S0MZL1_9BURK        Unreviewed;       739 AA.
AC   A0A2S0MZL1;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Adenylate/guanylate cyclase domain-containing protein {ECO:0000313|EMBL:AVO41338.1};
GN   ORFNames=C6571_08570 {ECO:0000313|EMBL:AVO41338.1};
OS   Simplicispira suum.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Simplicispira.
OX   NCBI_TaxID=2109915 {ECO:0000313|EMBL:AVO41338.1, ECO:0000313|Proteomes:UP000239326};
RN   [1] {ECO:0000313|EMBL:AVO41338.1, ECO:0000313|Proteomes:UP000239326}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC1-8 {ECO:0000313|EMBL:AVO41338.1,
RC   ECO:0000313|Proteomes:UP000239326};
RA   Kim S.-J., Heo J., Kwon S.-W.;
RT   "Genome sequencing of Simplicispira sp.";
RL   Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP027669; AVO41338.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S0MZL1; -.
DR   KEGG; simp:C6571_08570; -.
DR   OrthoDB; 9802500at2; -.
DR   Proteomes; UP000239326; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR007890; CHASE2.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF17; BLL5647 PROTEIN; 1.
DR   Pfam; PF05226; CHASE2; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM01080; CHASE2; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        394..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        420..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          484..616
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   739 AA;  79801 MW;  638C46DCADAC468B CRC64;
     MAWALVPVVL GVLHASGVLP LQLLERLEHL VYDVRLRLTL PHTLDERIVI IDIDESSLER
     VGRWPWSRDK MAAFTTELFE RQGVSVVGFD LVFAEADDSS GLKSLQQLSR GPLKDDARFA
     GEVDRLVPEL DFDARFASAL DTQNAVLGYY FTSDRDGKGR GALPAPVFTP QQLGDSALRA
     TEWNGYGSNI DVLARAAPAA GFFNAMADAD GLVRALPLLA EYQGRYYESL ALAVYRSLLG
     GADLMPAFAS AEADVGERRI LRGIALRHAG GRAFLPVDDQ LATLVPYRGS GGPLGGSFRY
     VSAADVLTGQ LAAGSLRGKV ALVGTTAVGL QDLRATPVGR TYPGVETHAN VLSGFLDGKA
     IYRPDYGPAY DVVQMMVAGL LLAFSLPLLG AGQALLLGGV VFAALVGLNG WLYLGFGLAL
     PLASALAVVL LVTALDMAYG YLTESRTKRG LAQLFGTYVP PELVDEMLLA PERYSMQAAS
     RELTVMFCDM RGFTAMSERM EPVQLQALLN DIFSRLTQAI RAQRGTIDKY MGDCVMAFWG
     APVPTPQHAA LAVRAALDMV KSVKLLNTQH RASGLPEIGI GIGLNTGSMC VGDMGSDIRR
     SYTVIGDAVN LGSRLEGLCK VYGVEIVASE ATRMQAPGFV WQELDRVRVK GKEDAVAIFC
     PLGEPGALTQ DQKSQLDQWH QALASLRAQD WAACDTQLEA LCAAAPENPV LAWYRERLAQ
     LRVLPYQPNW DGATRFDTK
//