ID A0A2S0P7R4_9NEIS Unreviewed; 718 AA.
AC A0A2S0P7R4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:AVY93365.1};
GN ORFNames=DAI18_04375 {ECO:0000313|EMBL:AVY93365.1};
OS Microvirgula aerodenitrificans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales;
OC Aquaspirillaceae; Microvirgula.
OX NCBI_TaxID=57480 {ECO:0000313|EMBL:AVY93365.1, ECO:0000313|Proteomes:UP000244173};
RN [1] {ECO:0000313|EMBL:AVY93365.1, ECO:0000313|Proteomes:UP000244173}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BE2.4 {ECO:0000313|EMBL:AVY93365.1,
RC ECO:0000313|Proteomes:UP000244173};
RA Anderson E., Jang J., Ishii S.;
RT "Denitrifier Microvirgula.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP028519; AVY93365.1; -; Genomic_DNA.
DR RefSeq; WP_028498088.1; NZ_CP028519.1.
DR AlphaFoldDB; A0A2S0P7R4; -.
DR STRING; 1122240.GCA_000620105_00616; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000244173; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AVY93365.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244173}.
FT DOMAIN 60..159
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 401..462
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 644..718
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 718 AA; 79703 MW; 3EEACEA8E6C4C9C2 CRC64;
MNSADAHTID YDAMVNAQAE ALLSTAATYL KPDDVPFLRT AFEFARDAHT GQTRKSGEPY
ITHPLAVAQI LTEWKLDAQG LAAALLHDTM EDTGVAKATL AERFGKQVAE LVDGLSKLER
LEYQSKESRQ AENFRKMVLA MARDIRVIII KLADRLHNMR TLDSMREEKR RRIAQETLDV
YTPIANRIGL NKVYRELEDL CFKHLYPNRY HVLSKAVKAA RGNRRELVGK IMQSLARKLL
EANIEATIRG REKNLYSIYH KMQEKHLSFS EVLDIYAFRV IVNDVPGCYL ALGALHGLYK
PIPGKFKDYI AIPKSNGYQS LHTTLFGPYG TPIEVQVRTR EMHKIAETGV ASHWMYKSGG
PTMDAARQRT HQWLQDILDI QAETGDAVEF YEHIKIDLFP DEVYVFTPKG KILVLPQGAT
PVDFAYAVHT DIGHRCIAAK VNHELVPLRT ELKNGDTVEV ITAAHSKPNP SWLNFVVSGR
ARSAIRSYLK TLHREEARVL GDRLLKQSIH SLAAQPFVLS DGVWSAYLKE VGDKNVKSTD
VLASIGAGKQ QAMVVAARLL ELAGEVLGGP ARSGPLVIRG NEGSSIQYAA CCSPLPGERI
AAALTKGQGM VLHTRDCAQL KRLDPDRVLD AEWEIRTPRL FSVPVTILAQ SARGALASVA
AAISEGGANI ESVDMQDAHH GEGYVQIHFR LQVGSAQHLN EVLNHILAQP LVERAVRG
//