ID   A0A2S0U831_9BACL        Unreviewed;       395 AA.
AC   A0A2S0U831;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Methionine biosynthesis PLP-dependent protein {ECO:0000313|EMBL:AWB43967.1};
DE            EC=2.5.1.48 {ECO:0000313|EMBL:AWB43967.1};
GN   ORFNames=DCC85_06850 {ECO:0000313|EMBL:AWB43967.1};
OS   Paenibacillus sp. CAA11.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1532905 {ECO:0000313|EMBL:AWB43967.1, ECO:0000313|Proteomes:UP000244407};
RN   [1] {ECO:0000313|EMBL:AWB43967.1, ECO:0000313|Proteomes:UP000244407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAA11 {ECO:0000313|EMBL:AWB43967.1,
RC   ECO:0000313|Proteomes:UP000244407};
RA   Um Y., Kim S., Gong G.;
RT   "Complete genome of CAA11.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; CP028922; AWB43967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S0U831; -.
DR   OrthoDB; 9780685at2; -.
DR   Proteomes; UP000244407; Chromosome.
DR   GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   PANTHER; PTHR11808:SF15; CYSTATHIONINE GAMMA-LYASE; 1.
DR   PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000244407};
KW   Transferase {ECO:0000313|EMBL:AWB43967.1}.
FT   MOD_RES         211
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   395 AA;  42630 MW;  75C83E091D920A56 CRC64;
     MAKSIQEALD PLNVRNTKLD TKLLHFGAEV DQATGASSVP LYQASTFHHA DIFNPPQYDY
     SRSGNPTRQA LEDYIALLEG GAAGYAFPSG MAAISTAFML FSAGDHLIVT EDVYGGTYRL
     LTGILGRLGI EASFVDMSRP DVVKAALRPN TKAVYMETPS NPTLKITDIA GISAWCKQQG
     LLSIVDNTFM TPYYQRPIEL GADIVLHSAT KFLGGHSDVL AGLAVTATKE LGSELKYLQN
     GLGSVLGVQD CWLLMRGMKT LGARMTHSEI SSRRIAEWLE GRSDIQAVYY PGLSSHPDRE
     IHAKQATGYG AVVSFDVGSG ERAKKVLNQV KLPLVAVSLG AVESILSYPA MMSHAAMPAE
     VRAERGITDG LLRFSVGLED VEDLMADLDQ ALDQE
//