ID   A0A2S0UGX7_9BACL        Unreviewed;       346 AA.
AC   A0A2S0UGX7;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=Metallo-beta-lactamase domain-containing protein {ECO:0000259|Pfam:PF12706};
GN   ORFNames=DCC85_21295 {ECO:0000313|EMBL:AWB47087.1};
OS   Paenibacillus sp. CAA11.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1532905 {ECO:0000313|EMBL:AWB47087.1, ECO:0000313|Proteomes:UP000244407};
RN   [1] {ECO:0000313|EMBL:AWB47087.1, ECO:0000313|Proteomes:UP000244407}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CAA11 {ECO:0000313|EMBL:AWB47087.1,
RC   ECO:0000313|Proteomes:UP000244407};
RA   Um Y., Kim S., Gong G.;
RT   "Complete genome of CAA11.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Counteracts the endogenous Pycsar antiviral defense system.
CC       Phosphodiesterase that enables metal-dependent hydrolysis of host
CC       cyclic nucleotide Pycsar defense signals such as cCMP and cUMP.
CC       {ECO:0000256|ARBA:ARBA00034301}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic CMP + H2O = CMP + H(+); Xref=Rhea:RHEA:72675,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58003,
CC         ChEBI:CHEBI:60377; Evidence={ECO:0000256|ARBA:ARBA00034221};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72676;
CC         Evidence={ECO:0000256|ARBA:ARBA00034221};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic UMP + H2O = H(+) + UMP; Xref=Rhea:RHEA:70575,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57865,
CC         ChEBI:CHEBI:184387; Evidence={ECO:0000256|ARBA:ARBA00034227};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:70576;
CC         Evidence={ECO:0000256|ARBA:ARBA00034227};
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DR   EMBL; CP028922; AWB47087.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S0UGX7; -.
DR   OrthoDB; 9805728at2; -.
DR   Proteomes; UP000244407; Chromosome.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR15032; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR   PANTHER; PTHR15032:SF4; N-ACYL-PHOSPHATIDYLETHANOLAMINE-HYDROLYZING PHOSPHOLIPASE D; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000244407}.
FT   DOMAIN          101..294
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF12706"
SQ   SEQUENCE   346 AA;  39309 MW;  60293F3ACB50629B CRC64;
     MVLYPPFGGK PDQERMEQAA KSLPYIDGKF TNPMPPPEAS GFGSSMLLLW DFIKRDPLRR
     PQGQLQVRTW APLAYSERER TAITWLGHSA SILEMDGKLL LLDPMLGRYP SSIPFIGGKR
     YGGLPVAPEE MPLIDLVLMS HDHYDHLDYR TIRKLKDKVG CFLVPLGVGA HLQRWGIDSS
     QIEELDWWEE SEYDGLKLAC TPARHSSGRR LRDRDTTLWC SWAIQGESRR IFFSGDSGYD
     KHFAEIGRKY GPFDAALMEC GQYDRRWSAV HMTPEQTIQA HLDVRGGLLL PVHWAAFTLA
     LHPWTEPVER AIQAAKQKGV TITTPEIGEK VILGEAPYPV SAWWRQ
//