ID   A0A2S0WHK4_9ACTN        Unreviewed;       334 AA.
AC   A0A2S0WHK4; A0A5F2ENG0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:AWB90808.1};
DE            EC=3.5.4.4 {ECO:0000313|EMBL:TGN31071.1};
GN   ORFNames=C3E78_00355 {ECO:0000313|EMBL:AWB90808.1}, E4L97_15825
GN   {ECO:0000313|EMBL:TGN31071.1};
OS   Aeromicrobium chenweiae.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Aeromicrobium.
OX   NCBI_TaxID=2079793 {ECO:0000313|EMBL:AWB90808.1, ECO:0000313|Proteomes:UP000244384};
RN   [1] {ECO:0000313|EMBL:AWB90808.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=592 {ECO:0000313|EMBL:AWB90808.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000244384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=592 {ECO:0000313|Proteomes:UP000244384};
RA   Li J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:TGN31071.1, ECO:0000313|Proteomes:UP000297606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S592 {ECO:0000313|EMBL:TGN31071.1,
RC   ECO:0000313|Proteomes:UP000297606};
RA   Li J., Ha Z., Lu H., Jin N.;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; CP026952; AWB90808.1; -; Genomic_DNA.
DR   EMBL; SRPI01000008; TGN31071.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S0WHK4; -.
DR   KEGG; aez:C3E78_00355; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000244384; Chromosome.
DR   Proteomes; UP000297606; Unassembled WGS sequence.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:TGN31071.1}.
FT   DOMAIN          8..330
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   334 AA;  35995 MW;  6DB591BD65ED6D53 CRC64;
     MSFETGLPKA ELHVHHVGSA SMRTVAELAE RHAGSTTVPT DPQKLAEFFT FTDFAHFIEV
     YLSVVDLLRT PEDLWTLTYD VARDLTAQNV RYVELTCTPY TSIAVGISAE AYCEALEDAR
     RRAEADFGLT MRWIFDIPGE SGLPAADVTL DTALRLQPDG LVGFGLGGPE IGVPRPQFKP
     HFDQARAAGL HSLPHAGEST GPQTIWDSLE ALGAERIGHG IAAAQDPALM AYLAEHQIPL
     EISPTSNIRT RSVPSMDAHP LPTLVAAGVP VSINSDDPPM FSTTISHEYE VARDLLGLDD
     AGVADLARAG VRQSYAPDAV KTRLLAEIDA YAIS
//