ID A0A2S0WQP4_9ACTN Unreviewed; 403 AA.
AC A0A2S0WQP4; A0A5F2EUJ7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Cobalamin biosynthesis bifunctional protein CbiET {ECO:0000313|EMBL:AWB93637.1};
DE SubName: Full=Precorrin-6y C5,15-methyltransferase (Decarboxylating) subunit CbiE {ECO:0000313|EMBL:TGN33287.1};
GN Name=cbiE {ECO:0000313|EMBL:TGN33287.1};
GN ORFNames=C3E78_16255 {ECO:0000313|EMBL:AWB93637.1}, E4L97_06270
GN {ECO:0000313|EMBL:TGN33287.1};
OS Aeromicrobium chenweiae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Aeromicrobium.
OX NCBI_TaxID=2079793 {ECO:0000313|EMBL:AWB93637.1, ECO:0000313|Proteomes:UP000244384};
RN [1] {ECO:0000313|Proteomes:UP000244384}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=592 {ECO:0000313|Proteomes:UP000244384};
RA Li J.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AWB93637.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=592 {ECO:0000313|EMBL:AWB93637.1};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:TGN33287.1, ECO:0000313|Proteomes:UP000297606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=S592 {ECO:0000313|EMBL:TGN33287.1,
RC ECO:0000313|Proteomes:UP000297606};
RA Li J., Ha Z., Lu H., Jin N.;
RL Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879}.
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DR EMBL; CP026952; AWB93637.1; -; Genomic_DNA.
DR EMBL; SRPI01000002; TGN33287.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S0WQP4; -.
DR KEGG; aez:C3E78_16255; -.
DR OrthoDB; 9787825at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000244384; Chromosome.
DR Proteomes; UP000297606; Unassembled WGS sequence.
DR GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd11644; Precorrin-6Y-MT; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR012818; CbiE.
DR InterPro; IPR006365; Cbl_synth_CobL.
DR InterPro; IPR014008; Cbl_synth_MTase_CbiT.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR02467; CbiE; 1.
DR NCBIfam; TIGR02469; CbiT; 1.
DR PANTHER; PTHR43182; COBALT-PRECORRIN-6B C(15)-METHYLTRANSFERASE (DECARBOXYLATING); 1.
DR PANTHER; PTHR43182:SF1; COBALT-PRECORRIN-7 C(5)-METHYLTRANSFERASE; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR PIRSF; PIRSF036428; CobL; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..186
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 403 AA; 41668 MW; D696099CE62F1EF8 CRC64;
MSTRVTVVGI GADGWAGLTE AARALIDHAP VVLGGERHLA MLPDTPDQIR ESWPSPLLEG
LPALLEQLDG HEVVALASGD PLVSGVATTL VGLLGKEAVT IVPAVSSVAL ARARMRWSAE
STEVVTLVGR DPHLVARSLA PGLRLIILSS DGSTPTEVAA LLTAAGYGAS RMSVLANLGS
ETESRLDGVA ATWSQDSPAL NVIAVELASS GATPLGFVAG LPDDAFEHDG QITKRDVRAS
ALARLAPVPG QLLWDVGAGA GSVGIEWLRA HPTCRAIAVE AKDERAERIG RNAAALGVPV
LQVVTGQAPG ALDGLERPHA IFVGGGATEP GLVEACWEAL LPGGRLVIHG VTLETEALLA
ERYARLGGEL TRLHVEHAAP IGRFTGWTPA RAVMQWAVTK ADA
//
