UniProt: A0A2S0WRH6

Database: UniProt
Entry: A0A2S0WRH6_9ACTN

LinkDB:  A0A2S0WRH6_9ACTN 
Original site:  A0A2S0WRH6_9ACTN

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Ontology (6)   
   GO (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (11)   
   InterPro (7)   
   Pfam (2)   
   PROSITE (1)   
   SMART (1)   
All databases (21)   

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ID   A0A2S0WRH6_9ACTN        Unreviewed;       472 AA.
AC   A0A2S0WRH6; A0A5F2ENP0;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Replicative DNA helicase {ECO:0000256|ARBA:ARBA00021957, ECO:0000256|RuleBase:RU362085};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551, ECO:0000256|RuleBase:RU362085};
GN   Name=dnaB {ECO:0000313|EMBL:AWB93922.1};
GN   ORFNames=C3E78_17840 {ECO:0000313|EMBL:AWB93922.1}, E4L97_15255
GN   {ECO:0000313|EMBL:TGN30967.1};
OS   Aeromicrobium chenweiae.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Aeromicrobium.
OX   NCBI_TaxID=2079793 {ECO:0000313|EMBL:AWB93922.1, ECO:0000313|Proteomes:UP000244384};
RN   [1] {ECO:0000313|Proteomes:UP000244384}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=592 {ECO:0000313|Proteomes:UP000244384};
RA   Li J.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AWB93922.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=592 {ECO:0000313|EMBL:AWB93922.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:TGN30967.1, ECO:0000313|Proteomes:UP000297606}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S592 {ECO:0000313|EMBL:TGN30967.1,
RC   ECO:0000313|Proteomes:UP000297606};
RA   Li J., Ha Z., Lu H., Jin N.;
RL   Submitted (MAR-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Participates in initiation and elongation during chromosome
CC       replication; it exhibits DNA-dependent ATPase activity.
CC       {ECO:0000256|ARBA:ARBA00002835, ECO:0000256|RuleBase:RU362085}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC         Evidence={ECO:0000256|ARBA:ARBA00001665,
CC         ECO:0000256|RuleBase:RU362085};
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
CC       {ECO:0000256|ARBA:ARBA00008428, ECO:0000256|RuleBase:RU362085}.
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DR   EMBL; CP026952; AWB93922.1; -; Genomic_DNA.
DR   EMBL; SRPI01000008; TGN30967.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S0WRH6; -.
DR   KEGG; aez:C3E78_17840; -.
DR   OrthoDB; 9773982at2; -.
DR   Proteomes; UP000244384; Chromosome.
DR   Proteomes; UP000297606; Unassembled WGS sequence.
DR   GO; GO:1990077; C:primosome complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006269; P:DNA replication, synthesis of RNA primer; IEA:UniProtKB-UniRule.
DR   CDD; cd00984; DnaB_C; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR036185; DNA_heli_DnaB-like_N_sf.
DR   InterPro; IPR007692; DNA_helicase_DnaB.
DR   InterPro; IPR007694; DNA_helicase_DnaB-like_C.
DR   InterPro; IPR007693; DNA_helicase_DnaB-like_N.
DR   InterPro; IPR016136; DNA_helicase_N/primase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00665; DnaB; 1.
DR   PANTHER; PTHR30153:SF2; REPLICATIVE DNA HELICASE; 1.
DR   PANTHER; PTHR30153; REPLICATIVE DNA HELICASE DNAB; 1.
DR   Pfam; PF00772; DnaB; 1.
DR   Pfam; PF03796; DnaB_C; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF48024; N-terminal domain of DnaB helicase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51199; SF4_HELICASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362085};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW   ECO:0000256|RuleBase:RU362085};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU362085};
KW   Helicase {ECO:0000256|RuleBase:RU362085, ECO:0000313|EMBL:AWB93922.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU362085};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU362085};
KW   Primosome {ECO:0000256|ARBA:ARBA00022515, ECO:0000256|RuleBase:RU362085}.
FT   DOMAIN          192..458
FT                   /note="SF4 helicase"
FT                   /evidence="ECO:0000259|PROSITE:PS51199"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  51045 MW;  AE883445450924C7 CRC64;
     MSVTDLYEAG PGPGEDPTSG RVPPQDIAAE QSVLGAMLIS KNAIDPAADI LQGRDFYRPA
     HELIFDTITD LANRGEPADA ITVAAELHRR GEMGRIGGAP YLHDLVQAVP IASNVDFYAE
     IVREKAILRR LVEVGQRIAQ LGQAGQGEVA EIVDRAQAEV LDVDGTSQAE DYRAVSELMP
     LTIDEIEEIQ GRDGSLSGVP SGFPDLDKFT TGFRAGQMIV VAARPGVGKS TLGLDFVRSA
     AIRHQIPCAI FSLEMTGAEI AMRMLSAEAR VSIGHMRGGG MHQRDWDAIT KAMPRVNSAP
     IIIDDSPNMT MPEIRSKARR IKKQYGLGFV VIDYLQLMTS GKRVENRQVE VSEFSRNIKL
     LAKEMEVPVV AISQLNRGSE QRTDKTPQIS DLRESGSIEQ DADIVLLLNR PDALGAGESD
     RPGEADIIIA KNRSGPTNKI AVSFQGHYSR FTPMARDAEP PPGAPAAGDF FG
//

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