ID A0A2S0WXU7_9MICO Unreviewed; 821 AA.
AC A0A2S0WXU7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=DCE93_11175 {ECO:0000313|EMBL:AWB96138.1};
OS Agromyces badenianii.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Agromyces.
OX NCBI_TaxID=2080742 {ECO:0000313|EMBL:AWB96138.1, ECO:0000313|Proteomes:UP000244729};
RN [1] {ECO:0000313|EMBL:AWB96138.1, ECO:0000313|Proteomes:UP000244729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=30A {ECO:0000313|Proteomes:UP000244729};
RA Li J.;
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP028913; AWB96138.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S0WXU7; -.
DR KEGG; agm:DCE93_11175; -.
DR OrthoDB; 9806690at2; -.
DR Proteomes; UP000244729; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000244729}.
FT DOMAIN 30..338
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 339..625
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 708..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 51..58
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 821 AA; 90017 MW; 19A5984E99DA0D32 CRC64;
MTLILDPDDP AGWREAPAVS ADHSGSRLTD GLNPEQREAV EYRGPALLIV AGAGSGKTRV
LTHRIASLIE SREAWPSQIL AITFTNKAAA EMRERVEALL GEGASGMWIS TFHSACVRIL
RREAESIGLS STFTIYDSAD QRTILKRIIK ELDADTMGFT PASAQSKISK LKNELTDVET
HARNANTNDP QEVMFLEIFR QYTRRLRAAS ALDFDDLIAE TVYLFRAFPK VAALYQRRFR
HILVDEYQDT NHAQYSLIHE LTRPVPREIV AELDEHGILV RGLTDASGAI PGASLTVVGD
SDQSIYAFRG ADIRNISEFE RDFPGAKVVL LEQNYRSTQN ILSAANAVIA NNFDRKEKKL
WTADGDGDKI TGYTGYTAHD EAQFIADEIE ALHRAGVAYR DIAVFYRTNA QTRALEEIFV
RSALPYRVVG GTKFYERAEI KDAMAYLIAV ANPADELALR RILNTPKRGI GPATETALAS
FAEQNELTFR QAMRAVDGLG LGPKVTGAIS ALANVLDEAA AMLVPSAEGI EAGTNAGAAK
VSDVLVFLME RSGLLDALRN SRDPQDETRA ENVEELVAQT RDFDRENPGA TLVDFLTQVS
LVAAADELDD ASGTVSLMTL HTAKGLEYHA VFLTGIEEGL LPHQMSASEP GGPAEERRLF
YVGITRARKR LYLSLAMSRA QFGEVAVAMP SRYLQEIPEG LIDWRQSPGM ATSRGGTQPR
ALNARRGAPG GAWGTRDRDL ERFSVTRSDK PKTEWANRVT GTVRDNGDLT LEAGDRIRHT
DFGEGTVTQV TGEGTKRIAH VGFDTAGQKK LLIKIAPIEK L
//
