ID A0A2S1JMS7_9GAMM Unreviewed; 721 AA.
AC A0A2S1JMS7;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:AWF79715.1};
GN ORFNames=BTJ40_02105 {ECO:0000313|EMBL:AWF79715.1};
OS Microbulbifer sp. A4B17.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=359370 {ECO:0000313|EMBL:AWF79715.1, ECO:0000313|Proteomes:UP000244764};
RN [1] {ECO:0000313|EMBL:AWF79715.1, ECO:0000313|Proteomes:UP000244764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4B17 {ECO:0000313|EMBL:AWF79715.1,
RC ECO:0000313|Proteomes:UP000244764};
RX PubMed=16885309; DOI=10.1128/AEM.00494-06;
RA Peng X., Adachi K., Chen C., Kasai H., Kanoh K., Shizuri Y., Misawa N.;
RT "Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl
RT esters, parabens.";
RL Appl. Environ. Microbiol. 72:5556-5561(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
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DR EMBL; CP029064; AWF79715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1JMS7; -.
DR KEGG; mii:BTJ40_02105; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000244764; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 452..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 494..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 495..534
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 536..602
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 611..696
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 294..359
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 721 AA; 82312 MW; 3DEAA80CA881D1AC CRC64;
MVGASLLIPR RIARNYSFFL RLFLPTLLLL AFTCLSVSTS AQLPGGKPKE FTPEVPDFAD
PSADWWTGWT NASPEERREW LSILITNWRE WEKDIPEDDE VLQEGAAKIS QSLQGITITW
KKREEYLKVS IMPDLEFPGN PTVLEWAKAD SEISRGRRRL KGVELQARQL KSTQSQSLSL
LRKQVIVLRD SSGREEDEAA QALLLAQINH LNIIEQLSTV NSFLGIWQDK IKEAETKLRR
MLDSLVYSSE DAKEIEDDIA SSDKKIERIS GTRTSIQSTT EPSTDPTINM QKDLTLMQLE
VDLLEEQLDK RKSELLQSIN EVLNEEGEER PLIISRDLLE NANTIIEDAS RELAVRQRQV
VAWRADEEDE DLSRWWSYFA RIGSGLARAN DLEQDIQRYE KAQLEVYRER QGWWATVRER
VSLGAREAYN RWRKLADYQL FTITQNPITP RLIAKIIVVL VGVWLLSGLT QAFLRRLVRR
EHASESSMYN LGRVLHYTFI AIALIVVLSM LGLDTSKLAL VAGALSVGIG FGLQAIFSNF
ISGLILLFER PLKVGDLVEL ESGVFGRIRD INVRSTRITT RDNVDILVPN TEFVAGRVIN
HTLDDPVRRI HVSFGVSYAS DPDLVREAAL EAASRVNITH TDWKRKTEVW LMGFGENSLD
FKLVVWVNSN MVTSLGDSYA LYNLELLREF REKGIEVPFP QRDLHLRSWD VPALVARPSR
K
//
