ID A0A2S1JRL9_9GAMM Unreviewed; 674 AA.
AC A0A2S1JRL9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=3-methylcrotonyl-CoA carboxylase {ECO:0000313|EMBL:AWF81050.1};
GN ORFNames=BTJ40_09625 {ECO:0000313|EMBL:AWF81050.1};
OS Microbulbifer sp. A4B17.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=359370 {ECO:0000313|EMBL:AWF81050.1, ECO:0000313|Proteomes:UP000244764};
RN [1] {ECO:0000313|EMBL:AWF81050.1, ECO:0000313|Proteomes:UP000244764}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4B17 {ECO:0000313|EMBL:AWF81050.1,
RC ECO:0000313|Proteomes:UP000244764};
RX PubMed=16885309; DOI=10.1128/AEM.00494-06;
RA Peng X., Adachi K., Chen C., Kasai H., Kanoh K., Shizuri Y., Misawa N.;
RT "Discovery of a marine bacterium producing 4-hydroxybenzoate and its alkyl
RT esters, parabens.";
RL Appl. Environ. Microbiol. 72:5556-5561(2006).
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
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DR EMBL; CP029064; AWF81050.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1JRL9; -.
DR KEGG; mii:BTJ40_09625; -.
DR OrthoDB; 9763189at2; -.
DR Proteomes; UP000244764; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 3..447
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 122..318
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 579..659
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 674 AA; 73235 MW; 7405C51B7421FAD2 CRC64;
MSTTETLLIA NRGEIALRIM RTARAEGYRT VAVYSEADCD ALHAQTADIA VAIGGQTSAG
SYLDIQKILA AAKKSGATAV HPGYGFLAEN AEFASACEEN GLSFVGPSAE VIELMGNKRK
AKEFVAAAGV PCIPGFQGAQ DDDTLVAEAR RIGFPLMIKA AAGGGGRGMR LAHGDNELAS
QLRAARSESM SAFGSDELIL EKALVNARHI EIQVFADRHG NCIHLGERDC SVQRRHQKVV
EECPSPAVDT QLRERMGQAA VDAARACGYL GAGTVEFLLC PNGEFYFLEM NTRLQVEHPV
TEMVTGFDLV AWQLAVARGE ALCVSQQQVS QQGHAIEVRL YAEDPEQQFL PQAGKVLHWV
APKGQGIRID HALKNGCEIT PFYDPMLGKL IAWGQDREKA RRKLTQALTR LEFIGPKNNI
HFLQKILAES QFIAGDADTS FLDQNSTLTS AEPVPAVIAA QATLLNHLHQ ANPQDRRSGR
SDWRSGDNSV PINYRLEIAG QTLNCELLAL VDNSYQISVG DQQFLIQWVH FEKSQKETGV
YSAELLLDGV SQKRLFLANQ SNLHLLLDGR QFHFVDITHA PAKSSLNEGS GRITAPMDGC
LVQVLVEPNQ RVQRGDTIAL MEAMKMEHAL RADRDGTVIK LGACEGDQVR GGQLLVQIEA
APTETAKIPS DATS
//
