ID A0A2S1LS33_9FLAO Unreviewed; 427 AA.
AC A0A2S1LS33;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=fumarylacetoacetase {ECO:0000256|ARBA:ARBA00012094};
DE EC=3.7.1.2 {ECO:0000256|ARBA:ARBA00012094};
GN ORFNames=FK004_15255 {ECO:0000313|EMBL:AWG26482.1};
OS Flavobacterium kingsejongi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1678728 {ECO:0000313|EMBL:AWG26482.1, ECO:0000313|Proteomes:UP000244677};
RN [1] {ECO:0000313|EMBL:AWG26482.1, ECO:0000313|Proteomes:UP000244677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AJ004 {ECO:0000313|EMBL:AWG26482.1,
RC ECO:0000313|Proteomes:UP000244677};
RA Lee P.C.;
RT "Complete genome sequence of Flavobacterium kingsejong AJ004.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC acetoacetate and fumarate from L-phenylalanine: step 6/6.
CC {ECO:0000256|ARBA:ARBA00004782}.
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DR EMBL; CP020919; AWG26482.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1LS33; -.
DR KEGG; fki:FK004_15255; -.
DR OrthoDB; 3766879at2; -.
DR UniPathway; UPA00139; UER00341.
DR Proteomes; UP000244677; Chromosome.
DR GO; GO:0004334; F:fumarylacetoacetase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006572; P:tyrosine catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.30.30.230; Fumarylacetoacetase, N-terminal domain; 1.
DR Gene3D; 3.90.850.10; Fumarylacetoacetase-like, C-terminal domain; 1.
DR InterPro; IPR005959; Fumarylacetoacetase.
DR InterPro; IPR011234; Fumarylacetoacetase-like_C.
DR InterPro; IPR036663; Fumarylacetoacetase_C_sf.
DR InterPro; IPR015377; Fumarylacetoacetase_N.
DR InterPro; IPR036462; Fumarylacetoacetase_N_sf.
DR NCBIfam; TIGR01266; fum_ac_acetase; 1.
DR PANTHER; PTHR43069; FUMARYLACETOACETASE; 1.
DR PANTHER; PTHR43069:SF2; FUMARYLACETOACETASE; 1.
DR Pfam; PF01557; FAA_hydrolase; 1.
DR Pfam; PF09298; FAA_hydrolase_N; 1.
DR SUPFAM; SSF56529; FAH; 1.
DR SUPFAM; SSF63433; Fumarylacetoacetate hydrolase, FAH, N-terminal domain; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phenylalanine catabolism {ECO:0000256|ARBA:ARBA00023232};
KW Reference proteome {ECO:0000313|Proteomes:UP000244677};
KW Tyrosine catabolism {ECO:0000256|ARBA:ARBA00022878}.
FT DOMAIN 25..127
FT /note="Fumarylacetoacetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF09298"
FT DOMAIN 134..402
FT /note="Fumarylacetoacetase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01557"
SQ SEQUENCE 427 AA; 48009 MW; 1A18CA169C40A293 CRC64;
MPITANNPDR KSWLQVPENS DFPIQNIPFG VFLTKEHVVT IGTRIGNYAI DLGALQQLSY
FEGIELTDDM FMQDTLNDFI SDGKKTWRLV RNRIADIFDQ NNPELRDNTS HRDVVIFNIE
DVEMQLPILI GDYTDFYSSK EHATNVGKMF RDPDNALLPN WVHIPVGYHG RSSTIIPSGI
PVHRPMGQTL PNGETQPVFG PSRLVDFELE TAFITTDANI MGENIPIEEA EEYIFGMVLL
NDWSARDIQK WEYVPLGPFL AKNFASSISP WIVTLDALEP FRTSSPVQEP KPLAYLQQEG
DHAFDINLEV TIAPENVAPT LLSKSNFKYM YWTMSQQLTH HTVNGCRVNS GDMMGSGTIS
GSTPDSFGSM LELTWGGKNP ITMKDGTERK FINDGDTVTM TGYCQNDLVR IGFGEVSSKL
LPPFVRK
//
