ID A0A2S1LSZ0_9FLAO Unreviewed; 436 AA.
AC A0A2S1LSZ0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex {ECO:0000256|RuleBase:RU003423};
DE EC=2.3.1.- {ECO:0000256|RuleBase:RU003423};
GN ORFNames=FK004_17395 {ECO:0000313|EMBL:AWG26877.1};
OS Flavobacterium kingsejongi.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=1678728 {ECO:0000313|EMBL:AWG26877.1, ECO:0000313|Proteomes:UP000244677};
RN [1] {ECO:0000313|EMBL:AWG26877.1, ECO:0000313|Proteomes:UP000244677}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AJ004 {ECO:0000313|EMBL:AWG26877.1,
RC ECO:0000313|Proteomes:UP000244677};
RA Lee P.C.;
RT "Complete genome sequence of Flavobacterium kingsejong AJ004.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=(R)-lipoate; Xref=ChEBI:CHEBI:83088;
CC Evidence={ECO:0000256|ARBA:ARBA00001938,
CC ECO:0000256|RuleBase:RU003423};
CC -!- SIMILARITY: Belongs to the 2-oxoacid dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00007317, ECO:0000256|RuleBase:RU003423}.
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DR EMBL; CP020919; AWG26877.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1LSZ0; -.
DR KEGG; fki:FK004_17395; -.
DR OrthoDB; 9805770at2; -.
DR Proteomes; UP000244677; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR CDD; cd06849; lipoyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 4.10.320.10; E3-binding domain; 1.
DR InterPro; IPR003016; 2-oxoA_DH_lipoyl-BS.
DR InterPro; IPR001078; 2-oxoacid_DH_actylTfrase.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR036625; E3-bd_dom_sf.
DR InterPro; IPR004167; PSBD.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR43178; DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX; 1.
DR PANTHER; PTHR43178:SF5; LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL; 1.
DR Pfam; PF00198; 2-oxoacid_dh; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02817; E3_binding; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
DR SUPFAM; SSF47005; Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00189; LIPOYL; 1.
DR PROSITE; PS51826; PSBD; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003423};
KW Lipoyl {ECO:0000256|ARBA:ARBA00022823, ECO:0000256|RuleBase:RU003423};
KW Reference proteome {ECO:0000313|Proteomes:UP000244677};
KW Transferase {ECO:0000256|RuleBase:RU003423}.
FT DOMAIN 3..78
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
FT DOMAIN 123..163
FT /note="Peripheral subunit-binding (PSBD)"
FT /evidence="ECO:0000259|PROSITE:PS51826"
SQ SEQUENCE 436 AA; 46827 MW; 17E9BC48E012C1EE CRC64;
MARFELKLPK MGESVAEATI TNWLKEVGDT IEADEAVLEI ATDKVDSEVP SEVSGVLVEK
LFQKDDLVQV GQTIAIIEIS GGVVVEAPAT ETTTTTNNIQ AVENTITAAK ETVAQDFSNS
EKFFSPLVKN IAKEEGISVA ELESMNGSGK EGRVTKDDIL NYIKNRSSQP AVVPAVAQAQ
ASAAPVKAAE APKAAPVSVN GGDEIIEMDR MRKLISGYMV ASVQTSAHVQ SFIEVDVTNI
VKWRDKVKNA FEKREGEKLT FTPIFMEAVA KALKDFPGMN ISVDGDYIIK KKNINLGMAA
ALPNGNLIVP VIKNADQLNI VGMAKAVNDL GNRAKAGKLK PDDTQGGTYT VTNVGTFGSV
FGTPIINQPQ VGILALGAIR KVPAVIETPE GDFIGIRQKM FLSHSYDHRV VDGALGGSFV
KRVAEYLEAF DVNRDY
//
