ID A0A2S1SG45_9FLAO Unreviewed; 458 AA.
AC A0A2S1SG45;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=B12-binding domain-containing radical SAM protein {ECO:0000313|EMBL:AWI25365.1};
GN ORFNames=HYN49_05320 {ECO:0000313|EMBL:AWI25365.1};
OS Flavobacterium pallidum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2172098 {ECO:0000313|EMBL:AWI25365.1, ECO:0000313|Proteomes:UP000244937};
RN [1] {ECO:0000313|EMBL:AWI25365.1, ECO:0000313|Proteomes:UP000244937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYN0049 {ECO:0000313|EMBL:AWI25365.1,
RC ECO:0000313|Proteomes:UP000244937};
RA Yi H., Baek C.;
RT "Genome sequencing of Flavobacterium sp. HYN0049.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP029187; AWI25365.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1SG45; -.
DR KEGG; fpal:HYN49_05320; -.
DR OrthoDB; 9801424at2; -.
DR Proteomes; UP000244937; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000244937}.
FT DOMAIN 7..142
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 190..408
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 458 AA; 52536 MW; 5DF8946CDE79FFA7 CRC64;
MSVLLTHGYY LSSDPKEQRI MKPYPPLGLL YVSSYLHSKG MHNDVYDSTF YTKEDQLAFI
LEKKPRIVAI YTNLMTKTEV ISLMKILKLP EYGFPKIILG GPDVSYNIEN YLKAGADFLV
IGEGEETTFE LCGALLDGQS YADINGIAYL ENNIAVKTAA RVKFRELDEL PLPNRDAIPN
EKYLEIWKRN HGESSMTIST QRGCPYTCKW CSTAVYGQSY RRRPPEQVAA EMKMLKEKYN
PDAIWFVDDV FTISHKWLTA FHEEVVKQGA QIRFECITRA ERLNEEILRL LKEAGCFRIW
IGAESGSQKI IDAMDRRVDV NHVKKMIQDT NALGIETGTF IMVGYPGETE ADISETIQYL
KDANPTHYTI TIAYPIKGTS LYEEIEKDIT VAPDWETSTD REIDFRREYP RKYYDYAVSK
VVNEVEFHRA FSKNHFSVKA VKHKAKSFLA TALMSLSK
//
