ID A0A2S1SHF8_9FLAO Unreviewed; 616 AA.
AC A0A2S1SHF8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149,
GN ECO:0000313|EMBL:AWI25846.1};
GN ORFNames=HYN49_07985 {ECO:0000313|EMBL:AWI25846.1};
OS Flavobacterium pallidum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2172098 {ECO:0000313|EMBL:AWI25846.1, ECO:0000313|Proteomes:UP000244937};
RN [1] {ECO:0000313|EMBL:AWI25846.1, ECO:0000313|Proteomes:UP000244937}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HYN0049 {ECO:0000313|EMBL:AWI25846.1,
RC ECO:0000313|Proteomes:UP000244937};
RA Yi H., Baek C.;
RT "Genome sequencing of Flavobacterium sp. HYN0049.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; CP029187; AWI25846.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1SHF8; -.
DR KEGG; fpal:HYN49_07985; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000244937; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:AWI25846.1};
KW Hydrolase {ECO:0000313|EMBL:AWI25846.1};
KW Nuclease {ECO:0000313|EMBL:AWI25846.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000244937}.
FT DOMAIN 209..327
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 432..574
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 616 AA; 69429 MW; C4A14925D4118D12 CRC64;
MSSIIQLLPD HVANQIAAGE VVQRPASVVK ELLENAVDAK ATDIKLIIKD AGKSLVQVID
NGLGMSVTDA RLCFERHATS KIRQAEDLFS LHTKGFRGEA LASIAAIAHV EMKTRPDQEE
LGTHIVIEGS KFMSQDVAVL PKGTSFAVKN LFFNIPARRN FLKSDIVEQR HIIDEFLRVV
MAHPNIHFTL YHNGSEVFNL PQSNIRQRIV NIFGGKTNEK LVPVKETTDI VSIQGFVSKP
EFSKKSRGEQ FFFVNDRFIK SGYLHHAVMA AYEGLLKDGC QPAYYLYLDV PPHTIDINIH
PTKTEIKFDD EHALYAILRS AIKHSLGQFN VAPVLDFERD PNLDTPYDYK NQEASVPLIQ
VDANFNPFSD DKPSKPSYST YKKPDTSHWE GLYVGLRQET ETLTAPVEIH FEQEEVTASL
FDDHEQEQQT VKLFQIHKKY IVNPIKSGMI IVDQQRAHQR ILYEKFLTNM TVRQAASQQL
LFPLTLYFSR QEIELIAELQ ESLVNTGFVF ESMADDHAVI SGLPVNVAES EVSILLEQLL
GDLQDGIPDS SFSQNDSIAK SMARSLAVKT GTFLNEKEQE NIVNGLFACK DPNVSPFHKP
TFITMRVEDL DKKFAL
//
