ID A0A2S1YW10_9ACTN Unreviewed; 1587 AA.
AC A0A2S1YW10;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=BREX system serine/threonine kinase PglW {ECO:0000313|EMBL:AWK08279.1};
GN Name=pglW {ECO:0000313|EMBL:AWK08279.1};
GN ORFNames=DDQ41_04260 {ECO:0000313|EMBL:AWK08279.1};
OS Streptomyces spongiicola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1690221 {ECO:0000313|EMBL:AWK08279.1, ECO:0000313|Proteomes:UP000245051};
RN [1] {ECO:0000313|EMBL:AWK08279.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HNM0071 {ECO:0000313|EMBL:AWK08279.1};
RA Zhou S., Huang X.;
RT "Complete genome sequence of the Type Strain of Streptomyces spongiicola
RT HNM0071, the producer of staurosporine.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP029254; AWK08279.1; -; Genomic_DNA.
DR KEGG; sspo:DDQ41_04260; -.
DR OrthoDB; 3404503at2; -.
DR Proteomes; UP000245051; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR011528; NERD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR NCBIfam; NF033442; BREX_PglW; 1.
DR PANTHER; PTHR24347:SF412; CALCIUM_CALMODULIN DEPENDENT PROTEIN KINASE I; 1.
DR PANTHER; PTHR24347; SERINE/THREONINE-PROTEIN KINASE; 1.
DR Pfam; PF08378; NERD; 1.
DR Pfam; PF00069; Pkinase; 2.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47789; C-terminal domain of RNA polymerase alpha subunit; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS50965; NERD; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|EMBL:AWK08279.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Transferase {ECO:0000313|EMBL:AWK08279.1}.
FT DOMAIN 12..130
FT /note="NERD"
FT /evidence="ECO:0000259|PROSITE:PS50965"
FT DOMAIN 148..494
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 537..826
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 499..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 571
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1587 AA; 171659 MW; 7A8535D688DD19E1 CRC64;
MREGRWVTVT ESEFDHERRG LDAIREKLPD SDPWRAWSNF TFTANTGHVR EVDLLVVAPG
GVCMVELKDW HGSVTSENGT WVQTTPGGRR RTHGNPLHLV NRKAKELAGL LALPGGKRVW
VAEAVCFTDS GLRIRLPAHD RNGVHTVHQL VEMLGQPPRD ERRRITAIGS REIEAALKSI
GIRKSDAQYK VGPYELERKS FDSGPTWADY LARHSDLPEA ARVRIYLSER GSDASLRQSV
ENAARREAAV LGRFKHPGVV ELKQYFPSGH AAGPALIFDY HPDTLKLDEY LVQYGGKLDI
LGRMALVRQL AETMRSAHSS RIHHRALAAR SVLVVPRPRG RKGRAVGEEA AWLTPQLQIS
DWQIATRRGG DSSQGLSQGQ GMTRLAPTAL SAQHLADDAD AYLAPELTAV RPDPVHLDVY
GLGVLTYLLV TGKAPAAGQA ELLARLEAGE GLRPSSLVDG LSEDVDFLVQ AATAYRPGQR
LSSVDEFLEL LEVVEDSLTA PAPAATGTEG PGDEDDDTAA GRDPLEAVAG DVLADRWEIR
RRLGTGSTSR AFLVRDLRAE TRRTRPLAVL KVALSDSRSE ILAREAEAMG RLRPHSGIIR
LVEPEPLHIG GRTVLALEYV GDERDDDGRP GEGTEGGGRP RRREETVARQ LRENGRLQVD
QLEAYGDYLF GAVDFLEGEG VWHRDIKPDN IAIRIRPNRT RELVLIDFSL AGYPARSTSA
GTDGYLDPFV DVITRGSYDS HAERYAVAVT LHQMASGELP RWGDGSVPPR MTDAKEWPYP
TIAAEAFDPA VRDGLVAFFQ KALHRDAGRR FPELKPMRDA WRKVFLDASR TVPSSHRSRP
PAATAAEEGT PAEGAAAAIA DAEPETAEQQ RDRLAAEVTR DTPLSVSGLT PAAQSFLYAL
GITTVGELLD YSRRKLVNAP GLGARTRNEV QQRQREWGER LRGIPVSPLT PKGRAEAREE
LEQLTAAESA LVGELASGAS AGALSPRMLR SVSLDTLATV FVPAVNNNGS NRNKAEMVRL
LLRLPDEHGA LPGIGVWPKQ KDVAEGLGLS HGRIPQLLKD ERKRWKAEPA VRALREEIVD
LLLGMGRVAS AVEIADALAV RRGTHLAGRE QRRAMALAAV RAVVEVEQLL PQEAEFQHQP
NRRATDESLG AGLLALDVRE NDGPDTPTAP GLLEYATRLG RTADRLARLD TLPTAATVLA
ELGALTVPPG AVDWDERRMV ELAAAASVNA AATPRLEIYP RDLPLVRALR LTQAGLVRWI
PGMPEGLQPG LTAEAVHERV RARFPEMIVP DGRGGTTQDL PTGGPLTKAL RDAGFELSLS
MHEREGVLRY LPTRVDDASS CLTTGAWRQS TRTGAVTRYA DDPQLAGAVR AEERLLASAR
RDGYRVLTVG QRSVREAVAG LAGERLGAEA VSVTALFLQA LHAQITPGTK PTWETLLRAD
AAEPGSKGAV RFAEYARTAW GAVEPRIAEL LGDGGGRGTG PGTGPVGPVL LTEAGVFARY
DAMGVLHRLA SAARRGGRGL WLLVPQPDPA REPRLGQVAV PYQAGLGEWI QLPDTWVGNA
HRGSGEVVTS AGAGAGAGAG VGGGDVE
//
