ID A0A2S1YX17_9ACTN Unreviewed; 724 AA.
AC A0A2S1YX17;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Penicillin-binding protein 2 {ECO:0000313|EMBL:AWK08664.1};
GN Name=mrdA {ECO:0000313|EMBL:AWK08664.1};
GN ORFNames=DDQ41_06690 {ECO:0000313|EMBL:AWK08664.1}, SSP531S_14600
GN {ECO:0000313|EMBL:GBQ00052.1};
OS Streptomyces spongiicola.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1690221 {ECO:0000313|EMBL:AWK08664.1, ECO:0000313|Proteomes:UP000245051};
RN [1] {ECO:0000313|EMBL:AWK08664.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HNM0071 {ECO:0000313|EMBL:AWK08664.1};
RA Zhou S., Huang X.;
RT "Complete genome sequence of the Type Strain of Streptomyces spongiicola
RT HNM0071, the producer of staurosporine.";
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GBQ00052.1, ECO:0000313|Proteomes:UP000265354}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=531S {ECO:0000313|EMBL:GBQ00052.1,
RC ECO:0000313|Proteomes:UP000265354};
RA Dohra H., Kodani S.;
RT "Whole Genome Shotgun Sequence of Streptomyces spongiicola strain 531S.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the transpeptidase family.
CC {ECO:0000256|ARBA:ARBA00007171}.
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DR EMBL; CP029254; AWK08664.1; -; Genomic_DNA.
DR EMBL; BGZL01000003; GBQ00052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S1YX17; -.
DR KEGG; sspo:DDQ41_06690; -.
DR OrthoDB; 9766847at2; -.
DR Proteomes; UP000245051; Chromosome.
DR Proteomes; UP000265354; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:InterPro.
DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR005311; PBP_dimer.
DR InterPro; IPR036138; PBP_dimer_sf.
DR InterPro; IPR001460; PCN-bd_Tpept.
DR InterPro; IPR017790; Penicillin-binding_protein_2.
DR NCBIfam; TIGR03423; pbp2_mrdA; 1.
DR PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR Pfam; PF03717; PBP_dimer; 1.
DR Pfam; PF00905; Transpeptidase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 60..245
FT /note="Penicillin-binding protein dimerisation"
FT /evidence="ECO:0000259|Pfam:PF03717"
FT DOMAIN 298..657
FT /note="Penicillin-binding protein transpeptidase"
FT /evidence="ECO:0000259|Pfam:PF00905"
FT REGION 678..724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 78883 MW; 999E51D72BAF7920 CRC64;
MSNIPETGRT PRVQIRLIVI QVLVFSLFAT LGGRLWYLQI RNGDEYTNEA KGNHVQQVVQ
PAVRGSILDA RGVPLADNET RLVVSASRTD LMRMKDDGKG VLTRLAEVLG MKPKDVMDKV
RLCDAKTPQP CWNGSPYQPI PVTDEATTQQ ALQIRERAED FPGITAEPMA VRRYAAPGEA
NTAQVLGYLS PVTDEEIEKA KDTDSPFLRS DQVGRSGLER TYDKDLRGKA GVTRYEVDKL
GRVIGLAQAD KAEPGANVVT SIDARVQAVA EWELDNAMKE ARKVFDDNTN TNYKADSGAV
VVMEARTGRV VAMASLPTYD PNAWVGGISA KDYARLTGKK SNFPLLNRAI QGQAAPGSIF
KVIPTTAAVN AGYDFNGRYP CPSSYSIGNQ VFKNFESQGH GSITLGQALE VSCDTVYYAL
AHQQWKKDGG LKPKDDPADW FYKTAHQFGL GAETGIDLPN EVTGRVPDRR WKQKFWEANK
DYWCKIGKKG GDYIQQLSYE NCLEGNLMRA GDSVNYSIGQ GDTLVTPIQM ATIYAAISNG
GTMWNPTVGK AVISADGRSI REIEPESHGK LPMDARTRKL MNEALAGVAT RGTAAWRFGG
WPQDKIPMHA KTGTAEVHGK QTTSWFATYT KDYSIVMTIS QGGTGSGASG PAVRNIYNAL
YGLDMEGNQD LGKALLPQPQ KTLPKVQPDG SIDAPKITPY APAQPEPEED TSLAGPPPAT
GRRD
//