ID   A0A2S1Z065_9ACTN        Unreviewed;       537 AA.
AC   A0A2S1Z065;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:AWK09653.1};
GN   ORFNames=DDQ41_12795 {ECO:0000313|EMBL:AWK09653.1};
OS   Streptomyces spongiicola.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1690221 {ECO:0000313|EMBL:AWK09653.1, ECO:0000313|Proteomes:UP000245051};
RN   [1] {ECO:0000313|EMBL:AWK09653.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HNM0071 {ECO:0000313|EMBL:AWK09653.1};
RA   Zhou S., Huang X.;
RT   "Complete genome sequence of the Type Strain of Streptomyces spongiicola
RT   HNM0071, the producer of staurosporine.";
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
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DR   EMBL; CP029254; AWK09653.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S1Z065; -.
DR   KEGG; sspo:DDQ41_12795; -.
DR   OrthoDB; 9771883at2; -.
DR   Proteomes; UP000245051; Chromosome.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
FT   DOMAIN          3..181
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          184..280
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          421..503
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   REGION          504..537
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   537 AA;  55974 MW;  106251F033B2E9E5 CRC64;
     MRIRIVGAGV MGRGIAQWAA AAGHTVELGD ARQEAVGDAI GFVRRMLDRS AAKGRLTPEA
     ARAASERLLP LDDAFAPGDG VELVIEAVRE DLATKTDLFR RLEDVLPART ILATNTSSLP
     VTRVAAGLAD PSRLVGLHFF NPVPLMRIVE VVPGVLTRPD IPPALVELVQ ATGHSAAVVA
     DTPGFLVNHA GRGLVTEALA LLEESVSDPA GIDRIARDVL GLRMGPFELM DLTGLDVTDT
     VIDGVWRGFR HSDRLRPSYL TPNRVAAGLH GRKTGRGFYD HVDGAQATPP EPPITGDPGR
     PVRVAGHGPD ADALRRTLRE DGATLEDDGA DPSGRAVVLV PTWGTTLAEQ IASAGLPASR
     TVGVDPLAMP TGRRVLAFTP ATDPAAVHDA RAVLARAAAP AHHDGTDGHR AVSVVRDTAG
     SVAQRLLASI VSVAASIAER SIATPAAVDT AVTAGLGYPT GPLAWGDRIG AARMLALQAG
     LHRSTGDPRY RPTRWVTERV HLGLPLTEPG PDPVALGATS PPPRSGTAEP THEGDGA
//