ID   A0A2S3QJ80_9FIRM        Unreviewed;       248 AA.
AC   A0A2S3QJ80;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=CO251_03695 {ECO:0000313|EMBL:POB11682.1};
OS   Sulfobacillus sp. hq2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales;
OC   Clostridiales Family XVII. Incertae Sedis; Sulfobacillus.
OX   NCBI_TaxID=2039167 {ECO:0000313|EMBL:POB11682.1, ECO:0000313|Proteomes:UP000237334};
RN   [1] {ECO:0000313|EMBL:POB11682.1, ECO:0000313|Proteomes:UP000237334}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=hq2 {ECO:0000313|Proteomes:UP000237334};
RA   He Q., Li Y., Han Y., Zhao W., Huang Z.;
RT   "Draft genome sequence of Sulfobacillus sp. hq2.";
RL   Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family.
CC       {ECO:0000256|ARBA:ARBA00009667, ECO:0000256|RuleBase:RU003657}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POB11682.1}.
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DR   EMBL; NWUL01000023; POB11682.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S3QJ80; -.
DR   Proteomes; UP000237334; Unassembled WGS sequence.
DR   GO; GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity; IEA:InterPro.
DR   GO; GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006062; His_biosynth.
DR   InterPro; IPR044524; Isoase_HisA-like.
DR   InterPro; IPR011060; RibuloseP-bd_barrel.
DR   PANTHER; PTHR43090; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR   PANTHER; PTHR43090:SF2; 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO] IMIDAZOLE-4-CARBOXAMIDE ISOMERASE; 1.
DR   Pfam; PF00977; His_biosynth; 1.
DR   SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605,
KW   ECO:0000256|RuleBase:RU003657};
KW   Histidine biosynthesis {ECO:0000256|ARBA:ARBA00023102,
KW   ECO:0000256|RuleBase:RU003657};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237334}.
SQ   SEQUENCE   248 AA;  26833 MW;  652ECBDDC2CFD90C CRC64;
     MEVCPVTLNM TDSFCVVPVI HISSGRVIRW QGDHPVRYTG ANANPLSMAL QWAARGARHL
     HVVDLDASHG RMSVVPALLM AMSKRPIAIS VGGGIYNVET AQQRMAYGAT HLVAGSLLAQ
     DHMTRRVARV VGSQRLWGSF LVANGALVAP DAAQRLDNAR RHGITTIILT ARHPENMAHP
     NNLRLIEAVR RQGFSVWTSG QIDDVQDIIP MYQAGAQGVL IGRALHEGLL SVDGIRSAME
     QLGAHIIA
//