ID A0A2S3ZVN8_ARTGL Unreviewed; 706 AA.
AC A0A2S3ZVN8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN ORFNames=CVS27_12190 {ECO:0000313|EMBL:POH73253.1};
OS Arthrobacter glacialis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1664 {ECO:0000313|EMBL:POH73253.1, ECO:0000313|Proteomes:UP000237061};
RN [1] {ECO:0000313|EMBL:POH73253.1, ECO:0000313|Proteomes:UP000237061}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HLT2-12-2 {ECO:0000313|EMBL:POH73253.1,
RC ECO:0000313|Proteomes:UP000237061};
RA Liu Q., Xin Y.-H.;
RT "Arthrobacter sp. nov., from glaciers in China.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POH73253.1}.
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DR EMBL; PPXC01000008; POH73253.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S3ZVN8; -.
DR OrthoDB; 9802808at2; -.
DR Proteomes; UP000237061; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0034335; F:DNA negative supercoiling activity; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR002288; DNA_gyrase_B_C.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF00986; DNA_gyraseB_C; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:POH73253.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237061};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 479..593
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
SQ SEQUENCE 706 AA; 77309 MW; 176AD62A3B072DA0 CRC64;
MSTVARQSSD YSARHLSVLE GLEAVRKRPG MYIGSTDSRG LMHCLWEIID NSVDEALAGY
GQHITVILHK DSSVEVHDDG RGIPVDVEPK TGLSGVEVVL TKLHAGGKFG GSSYAASGGL
HGVGASVVNA LSARMDAQVD RGGKTYQMSF RRGEPGHFKD VGKSLSPDVP FEPFVEKSGL
DIVGTTKRGV TGTRIRYWAD PQIFTKDARF SYEELVSRAR QTSFLVPGLR LRVVDERRVP
GTPGEFATHE EVFHHDGGIS EFVDFLAVGG GVTDIWRLQG HGTFTETVPV LNAEGRLEST
AVERDCEVDI ALRWGVGYDT TMRSFVNIIA TPKGGRHQEG FEQALLKTFR KVIETNARKL
KAGNDKVEKD DVMAGLTAVL TVRLAEPQFE GQTKEILGTP AVKNIVARVV ENELKEKLNS
TARGEKIQAA TLLEKVVSEM KSRISARVHK ETQRRKTALE SSSLPTKLAD CRSNDVAKTE
LFIVEGDSAL GTAKLARSSD FQALLPIRGK ILNVQKASVG DMLANAECAA LIQVVGAGSG
RSFDVSAARY GKVILMTDAD VDGAHIRTLL LTLFFRYMRP MIDAGNVYAA VPPLHRVEVI
NAGAKANEMI YTYSEKELHT VLAKLEKTNK KYKIPIQRYK GLGEMDAEQL AETTMDPRHR
MLRRVTSADA DRAEHTFELL MGSEVAPRKE FIVAGSEYLD QGRIDA
//
