ID A0A2S4HJM9_9GAMM Unreviewed; 619 AA.
AC A0A2S4HJM9;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=C0068_02715 {ECO:0000313|EMBL:POP54197.1};
OS Marortus luteolus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Spongiibacteraceae; Marortus.
OX NCBI_TaxID=2067667 {ECO:0000313|EMBL:POP54197.1, ECO:0000313|Proteomes:UP000237222};
RN [1] {ECO:0000313|EMBL:POP54197.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZX-21 {ECO:0000313|EMBL:POP54197.1};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POP54197.1}.
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DR EMBL; PQGG01000007; POP54197.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4HJM9; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000237222; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03482; MutL_Trans_MutL; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Endonuclease {ECO:0000313|EMBL:POP54197.1};
KW Hydrolase {ECO:0000313|EMBL:POP54197.1};
KW Nuclease {ECO:0000313|EMBL:POP54197.1}.
FT DOMAIN 213..331
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 432..575
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
FT REGION 384..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 619 AA; 68656 MW; 3F9FB14BACC9F26C CRC64;
MTKIRLLDPR LANQIAAGEV VERPASVVKE LLENSLDAGA RRIELEIEDG GVKLIRVRDD
GEGIAQEDLP LALSRHATSK ISALEDLESV ASLGFRGEAL ASISSVSRLS LSTAREGSDS
GWSARSEGRD MEAVLAPIAH PRGTTVEVRD LFFNTPARRK FLRTEKTEFS HLEDVVKRQA
LSRYDVGFSL RHNGRAVHSL KPADNQLEQE RRLAAVCGPA FMEQALYIDR EAMGLRLWGW
VALPSFSRSQ ADLQHFYVNG RYVRDRLVVH AVRQAYRDVL FHGRHPAFVL YLELAPASVD
VNVHPTKHEV RFRDGRTVHD FIFRTLHKVL ADVRPDTVPQ NASLPQVSGE PMLAMPETQS
AMALADNTAE SSPELVSPMN SAGAYQSQYR PQPSSFQPSS VADQQAAYQR LQAAPQNNGA
AEDGLAPPLG YALAQLKGVY ILAENQQGLV LVDMHAAHER ITYERMKNAR DGEGIRSQPL
LVPMNLAVSE READCAEQHG DVFAELGMRI ERAAAESVIV RELPTILADT SVEQLVRDVL
SDLLEFGSSD RIRAHINEIL STMACHGSVR ANRRLSLPEM NSLLRDMEAT ERSGQCNHGR
PTWVQVGMAE LDKWFLRGR
//
