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Database: UniProt
Entry: A0A2S4HJY4_9GAMM
LinkDB: A0A2S4HJY4_9GAMM
Original site: A0A2S4HJY4_9GAMM 
ID   A0A2S4HJY4_9GAMM        Unreviewed;       549 AA.
AC   A0A2S4HJY4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE            EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN   ORFNames=C0068_03055 {ECO:0000313|EMBL:POP54259.1};
OS   Marortus luteolus.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Spongiibacteraceae; Marortus.
OX   NCBI_TaxID=2067667 {ECO:0000313|EMBL:POP54259.1, ECO:0000313|Proteomes:UP000237222};
RN   [1] {ECO:0000313|EMBL:POP54259.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZX-21 {ECO:0000313|EMBL:POP54259.1};
RA   Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC         N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC         COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC         Evidence={ECO:0000256|ARBA:ARBA00001279};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00006594}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POP54259.1}.
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DR   EMBL; PQGG01000007; POP54259.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4HJY4; -.
DR   OrthoDB; 9784823at2; -.
DR   Proteomes; UP000237222; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1260.30; -; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR022749; D12N6_MeTrfase_N.
DR   InterPro; IPR003356; DNA_methylase_A-5.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR038333; T1MK-like_N_sf.
DR   PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR   PANTHER; PTHR42933:SF4; TYPE I RESTRICTION ENZYME ECOKI M PROTEIN; 1.
DR   Pfam; PF12161; HsdM_N; 1.
DR   Pfam; PF02384; N6_Mtase; 1.
DR   PRINTS; PR00507; N12N6MTFRASE.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS00092; N6_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:POP54259.1};
KW   Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW   Transferase {ECO:0000313|EMBL:POP54259.1}.
FT   DOMAIN          7..122
FT                   /note="N6 adenine-specific DNA methyltransferase N-
FT                   terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12161"
FT   DOMAIN          132..421
FT                   /note="DNA methylase adenine-specific"
FT                   /evidence="ECO:0000259|Pfam:PF02384"
SQ   SEQUENCE   549 AA;  60923 MW;  28CCE1E6C0377248 CRC64;
     MTNNDIVQKL WNLCDVLRDD GINYSDYVTE LVMLLFMKMV HENTESDLLK THILPEGCRW
     TDLSSKSGLN LLDDYKRILL ALSSGKDANG KQVHNDLLIS AVYADAQTRL REPRHLEQLV
     KALDQIDWYS AQQDGLGDLY EGLLEKNASE TKSGAGQYFT PRALINSMVR CIQPQAGETV
     QDPAAGTAGF LIAADAYIKQ HTDDLFDLPA KDQKFQRNNA FLGVELVPST RRMALMNCLL
     HGMEGDDEGV VHLGNALGMV GANLAKADII LANPPFGTSK GGDASITRDD LTYKTSNKQL
     AFLQHIYRNL KPGGRAAVVL PDNVLFEAGV GNEVRRDLMN KCNLHTILRL PTGIFYAQGV
     KTNVLFFTKG HPKDKLQDEN CTANVWVYDL RTNMPSFGKR TPFTEEHLKP FEDCYFAKNK
     KATAKDGGSV ENAGAIFDRM EGDYSFNAKE ADTTEEAGSN DDLAKSRWRV FSRDWIRDSK
     GDSLDISWLK DKDSVDAANL PEPEVLAAEA MSELTEALRE MDGLMQALGA GDEAAVQRML
     VHEILCESK
//
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