ID A0A2S4KS25_9HYPO Unreviewed; 768 AA.
AC A0A2S4KS25;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 28-JUN-2023, entry version 17.
DE RecName: Full=Vacuolar protein 8 {ECO:0000256|ARBA:ARBA00026209, ECO:0000256|RuleBase:RU369097};
GN ORFNames=TPAR_06795 {ECO:0000313|EMBL:POR33003.1};
OS Tolypocladium paradoxum.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX NCBI_TaxID=94208 {ECO:0000313|EMBL:POR33003.1, ECO:0000313|Proteomes:UP000237481};
RN [1] {ECO:0000313|EMBL:POR33003.1, ECO:0000313|Proteomes:UP000237481}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRBC 100945 {ECO:0000313|EMBL:POR33003.1,
RC ECO:0000313|Proteomes:UP000237481};
RA Quandt C.A., Patterson W., Spatafora J.W.;
RT "Harnessing the power of phylogenomics to disentangle the directionality
RT and signatures of interkingdom host jumping in the parasitic fungal genus
RT Tolypocladium.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in both vacuole inheritance and protein targeting
CC from the cytoplasm to vacuole. {ECO:0000256|ARBA:ARBA00024821,
CC ECO:0000256|RuleBase:RU369097}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004635}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004592, ECO:0000256|RuleBase:RU369097}.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462, ECO:0000256|RuleBase:RU369097}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POR33003.1}.
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DR EMBL; PKSG01000759; POR33003.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4KS25; -.
DR STRING; 94208.A0A2S4KS25; -.
DR OrthoDB; 2721872at2759; -.
DR Proteomes; UP000237481; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0071562; P:nucleus-vacuole junction assembly; IEA:InterPro.
DR GO; GO:0000011; P:vacuole inheritance; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045156; Vac8.
DR PANTHER; PTHR47249; VACUOLAR PROTEIN 8; 1.
DR PANTHER; PTHR47249:SF1; VACUOLAR PROTEIN 8; 1.
DR Pfam; PF00514; Arm; 7.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 7.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|RuleBase:RU369097};
KW Reference proteome {ECO:0000313|Proteomes:UP000237481};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554, ECO:0000256|RuleBase:RU369097}.
FT REPEAT 297..339
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 338..380
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 379..421
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 420..460
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 463..505
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 504..546
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 545..588
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 100..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 768 AA; 83747 MW; 30D4633147AD52B2 CRC64;
MRSERCKLEP RLRVANESAA KRLCGPTRRP LLATLDRRAQ VHPQGGAWRA LGEALDLVLG
SRRRCGFWRA PVAPPVALHH LTPTLTPALL LDIPQPPTTF AAPSAASPSR DPVALRRRPS
SWSSSPRRRS NPSIDSRSEH CLAASSDRRD VRPVGVGFEL RQQRHQSTAD VPPPPPLISI
RTQRPPQATN PAMGICHSTC CGGRARDGLY EPVLADSERE AVADLLQYLE NVRARLLRNE
SSSSLTSVQR GETDFFSGEP LRALSTLVFS ENIDLQRSAS LTFAEITERD VREVDRDTLE
PILFLLQSPD IEVQRAASAA LGNLAVNTEN KVLIVQLGGL TPLIRQMLSP NVEVQCNAVG
CITNLATHEE NKAKIARSGA LGPLTRLAKS RDMRVQRNAT GALLNMTHSD ENRQQLVNAG
AIPVLVQLLS SPDVDVQYYC TTALSNIAVD ANNRRKLASS EPKLVQSLVN LMDSSSPKVQ
CQAALALRNL ASDEKYQLDI VRANGLHPLL RLLQSSYLPL ILSAVACIRN ISIHPMNESP
IIEANFLKPL VDLLGSTDNE EIQCHAISTL RNLAASSDRN KALVLDAGAV QKCKQLVLDV
PVTVQSEMTA AIAVLALSDD LKSHLLNLGV CDVLIPLTHS PSIEVQGNSA AALGNLSSKV
GDYSIFVQNW NEPNGGIHGY LGRFLQSGDA TFQHIAVWTL LQLFESEDKA LIGLIGKADD
IIEHIRNITK RQVEAEPEFE EDEGEVVNLA QRCLELLGQS MSKAHIEG
//
