ID   A0A2S4L1D3_9HYPO        Unreviewed;       681 AA.
AC   A0A2S4L1D3;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Protein artemis {ECO:0000313|EMBL:POR36254.1};
GN   ORFNames=TPAR_03549 {ECO:0000313|EMBL:POR36254.1};
OS   Tolypocladium paradoxum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Tolypocladium.
OX   NCBI_TaxID=94208 {ECO:0000313|EMBL:POR36254.1, ECO:0000313|Proteomes:UP000237481};
RN   [1] {ECO:0000313|EMBL:POR36254.1, ECO:0000313|Proteomes:UP000237481}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRBC 100945 {ECO:0000313|EMBL:POR36254.1,
RC   ECO:0000313|Proteomes:UP000237481};
RA   Quandt C.A., Patterson W., Spatafora J.W.;
RT   "Harnessing the power of phylogenomics to disentangle the directionality
RT   and signatures of interkingdom host jumping in the parasitic fungal genus
RT   Tolypocladium.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the DNA repair metallo-beta-lactamase (DRMBL)
CC       family. {ECO:0000256|ARBA:ARBA00010304}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POR36254.1}.
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DR   EMBL; PKSG01000349; POR36254.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4L1D3; -.
DR   STRING; 94208.A0A2S4L1D3; -.
DR   OrthoDB; 23465at2759; -.
DR   Proteomes; UP000237481; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009058; P:biosynthetic process; IEA:UniProt.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR011084; DRMBL.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR23240; DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED; 1.
DR   PANTHER; PTHR23240:SF39; REPAIR PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04570)-RELATED; 1.
DR   Pfam; PF07522; DRMBL; 1.
DR   Pfam; PF12706; Lactamase_B_2; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237481}.
FT   DOMAIN          20..147
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF12706"
FT   DOMAIN          418..465
FT                   /note="DNA repair metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF07522"
FT   REGION          408..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          505..548
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          566..590
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          609..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..590
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        629..643
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   681 AA;  75266 MW;  57BF904B71CE28B1 CRC64;
     MSTFNGLVAE FPDIRIDFFR KHANAPPPLA CFLSHVHSDH LAGLDSLRSP FVYCSAATRE
     ILLRLERYPC RINYAQGILE ARQQTYRHLG KVLRLKKPLP LETPTIVELQ PGHHMQVTLF
     DANHCPGAVM FLIEGDGKSV LYTGDIRSEP WFVTTLARNP ILIEYTCGLK TLDKIYLDTS
     FISNVPFQTK ADGIAELLRK VSRYPNDTVF HIQAWTYGYE EVWIALSKAL KSPIHVDDYK
     MRIYNSLRSR PSEKQSAAEF HIAAGAAALT GHMCGNTPHP GCLTSNQNVR LHSCEKGEMC
     VEAKRPDVVR IQPIVARLPG GEKLVEAGVG GGGEDLEREA ELAFPFQEDL LVLLELISSS
     DAISEAEQGA IRSILGSMVA SGRSLSLNLD ASTFREGQST DLQTALRTLS HRSPSSAQQH
     TTSNNSTADG LPRVIQFPYS RHSSYPELCH LVKTFKPKDI WPCTVDPEQW VAEDISIKSL
     FGDCCSGQVF EHDLTMAALA AGPAPVESQA AESERMGLLS RREYSPERDT TSVEVASSPL
     ARPLPRDTSM QQRMVSLLPD SVPLGWQQQA SDESQLRDES PCRDTSDSRI DETVTAAQDS
     IVLARKRRHS ELGDAGENQA EACADDSQRT EDSSASAIST RDSLSRREAY CRMLDNATDD
     GWRPITLLST DGNHSVADEE L
//