ID A0A2S4LUC6_9BURK Unreviewed; 458 AA.
AC A0A2S4LUC6;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Multidrug efflux system membrane fusion protein {ECO:0000313|EMBL:POR46052.1};
GN ORFNames=B0G62_12734 {ECO:0000313|EMBL:POR46052.1};
OS Paraburkholderia eburnea.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1189126 {ECO:0000313|EMBL:POR46052.1, ECO:0000313|Proteomes:UP000237381};
RN [1] {ECO:0000313|EMBL:POR46052.1, ECO:0000313|Proteomes:UP000237381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 18070 {ECO:0000313|EMBL:POR46052.1,
RC ECO:0000313|Proteomes:UP000237381};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POR46052.1}.
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DR EMBL; PQGA01000027; POR46052.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4LUC6; -.
DR OrthoDB; 9783047at2; -.
DR Proteomes; UP000237381; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR PANTHER; PTHR30469:SF12; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000237381};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..50
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 114..161
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
FT DOMAIN 220..335
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 458 AA; 48380 MW; 6CEC25C3CFB23377 CRC64;
MDQQEKRPDS PRRDTPPSPA TGAAAPRKSR GKLIAIAVVL IVAAIVLLRW QPWNRNANGA
GAPNAASGGG RHMGRSGASA FANMPQPVSV ATATAGDMPI VITALGTVTP LADITVRTQL
SGTLQSVNFQ EGQMVNKGDV LAQIDPRPYQ ISLANAEGQL ARDQALLATA RLDLKRYQTL
LAQDSIASQQ VDTQASLVKQ YEGTVKSDQA NIDTYKLDLT YARVTAPVSG RVGLRQVDPG
NYVTPGDTNG LVVLTQLQPI SVIFTTSEDN LPSIMKQLHA GTKMSVAAYD RSNTTLLENG
FVQTIDNQID TTTGTVKLRA SFANNDQSLF PNQFVNARLL VDTIHNAVIV PTSAVLNGSQ
GQYVYVVKPD NTVTVRVVKV GPVDAERTSI ASGLAVGERV VIDGSDRLRE GAKITIPAEH
PRHASGARGA SGASWAGAAS GASGAHHHRR HASETSGQ
//
