ID A0A2S4LV29_9BURK Unreviewed; 398 AA.
AC A0A2S4LV29;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE SubName: Full=Macrolide-specific efflux system membrane fusion protein {ECO:0000313|EMBL:POR46302.1};
GN ORFNames=B0G62_12520 {ECO:0000313|EMBL:POR46302.1};
OS Paraburkholderia eburnea.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=1189126 {ECO:0000313|EMBL:POR46302.1, ECO:0000313|Proteomes:UP000237381};
RN [1] {ECO:0000313|EMBL:POR46302.1, ECO:0000313|Proteomes:UP000237381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 18070 {ECO:0000313|EMBL:POR46302.1,
RC ECO:0000313|Proteomes:UP000237381};
RA Whitman W.;
RT "Genomic Encyclopedia of Type Strains, Phase III (KMG-III): the genomes of
RT soil and plant-associated and newly described type strains.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POR46302.1}.
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DR EMBL; PQGA01000025; POR46302.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4LV29; -.
DR OrthoDB; 9784484at2; -.
DR Proteomes; UP000237381; Unassembled WGS sequence.
DR GO; GO:0019898; C:extrinsic component of membrane; IEA:InterPro.
DR GO; GO:1990195; C:macrolide transmembrane transporter complex; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.1990; -; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR030190; MacA_alpha-hairpin_sf.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30469:SF33; EFFLUX PROTEIN; 1.
DR PANTHER; PTHR30469; MULTIDRUG RESISTANCE PROTEIN MDTA; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000237381};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 14..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..265
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 398 AA; 42774 MW; 32516D94D16C25E6 CRC64;
MVPDKIPRVP GRKILVVLPL VLLAFLLWWT LLRTRTIVDT TPVGRGDIEL SVSALGTLQP
QSYVDVGAQA SGEIRRIAVQ PGSVVRKGDL LVEIDPSVQQ AKVDADHAVL DSLRAQLDGG
EASAVLARQQ DERQRRMDAE GATRAEDRQM AQATLRSAQA HVVDLRAQIA GASSTLKGDQ
AQLGYTRIYA PMAGTVITLD AREGQTLNAT YQTPKILRVA DLSTMTVWTE VSEADVRRVH
PGMPVYFTTL GDDRRWTGTV RQVLPAPPNA PADASSPTEV QKGAGTGGAG KVVLYTVLFD
VRNADHALMP QMSAQVFFVE ASAHGVVLAP LAALQAVAGK TDVYTAQVRT PGGDIVAREV
RTGVHDRLRA QVLAGLQPGE LLVTGIRRER AAAGRFQW
//
