ID   A0A2S4NB85_9FLAO        Unreviewed;       606 AA.
AC   A0A2S4NB85;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=CIC family chloride channel protein {ECO:0000313|EMBL:POS02713.1};
GN   ORFNames=Q361_10223 {ECO:0000313|EMBL:POS02713.1};
OS   Flavobacterium croceum DSM 17960.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Flavobacterium.
OX   NCBI_TaxID=1121886 {ECO:0000313|EMBL:POS02713.1, ECO:0000313|Proteomes:UP000237056};
RN   [1] {ECO:0000313|EMBL:POS02713.1, ECO:0000313|Proteomes:UP000237056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17960 {ECO:0000313|EMBL:POS02713.1,
RC   ECO:0000313|Proteomes:UP000237056};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase I: the one thousand microbial
RT   genomes (KMG-I) project.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POS02713.1}.
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DR   EMBL; PQNY01000002; POS02713.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4NB85; -.
DR   OrthoDB; 9812438at2; -.
DR   Proteomes; UP000237056; Unassembled WGS sequence.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   CDD; cd00400; Voltage_gated_ClC; 1.
DR   Gene3D; 3.10.580.10; CBS-domain; 1.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   PANTHER; PTHR43427; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   PANTHER; PTHR43427:SF6; CHLORIDE CHANNEL PROTEIN CLC-E; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237056};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        36..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        75..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        125..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        171..197
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        204..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        247..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        335..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        369..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        394..420
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   606 AA;  66658 MW;  508260E9FC49FCDC CRC64;
     MPARYLAKLQ IKLRRLFNYF EVFFVLAQEI LSNRNFIYLA SVAVGISCAL AVILLKTFAH
     KVFLFANYAN GYLKLPYANS IFPIIGILLT VFVIRNFLDG SIEKGSSRIL HAVAKKNGIM
     PRKQMYAQII TSSLTVGMGG SAGLESPITI TGAAFGSNFA QKYKLSQKDR ILLLACGVAA
     GIGAAFNAPI AGVLFAIEIV LVDVSISAFI PIIISAATGA LISTIVLSDN VLLHFTNVKK
     FDFHNTIYYI ILGVLAGLVA TYHAKNFRRV EHFFSKLKNN SYRKALMGAL VLAVLIFLFP
     TLFGEGYESI KALSTNNPSV ILENTLLEKY KDNDWVLLSF IGAIVMLKSF ATGLTLGSGG
     NGGNFAPSLF VGSYLGFFVA KSIGLLGINS HLPIANFAMV GMAGILSGLF HAPLTAIFLI
     GEITGGYELM VPLMIVSSIS FAVTRQFEKY SMDVKPLADS GEVFTSDKDK NILQSISLKK
     LIDTYNSIVY ADENLEKIVQ LYSTNKQTLF PVVDQQNQLI SYFYFNDINP YLLNQFRLKH
     TLIKDIAVNT QPIVSINDDL DAIMEIFDSC NYIELPIVHQ ASYIGSISKL KILEAYRTTC
     IDMQIE
//