GenomeNet

Database: UniProt
Entry: A0A2S4PIA4_9PEZI
LinkDB: A0A2S4PIA4_9PEZI
Original site: A0A2S4PIA4_9PEZI 
ID   A0A2S4PIA4_9PEZI        Unreviewed;       294 AA.
AC   A0A2S4PIA4;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=Uroporphyrinogen-III synthase {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
DE            EC=4.2.1.75 {ECO:0000256|ARBA:ARBA00013109, ECO:0000256|RuleBase:RU366031};
DE   Flags: Fragment;
GN   ORFNames=EPUL_005837 {ECO:0000313|EMBL:POS81779.1};
OS   Erysiphe pulchra.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Erysiphales; Erysiphaceae; Erysiphe.
OX   NCBI_TaxID=225359 {ECO:0000313|EMBL:POS81779.1, ECO:0000313|Proteomes:UP000237438};
RN   [1] {ECO:0000313|EMBL:POS81779.1, ECO:0000313|Proteomes:UP000237438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cflorida {ECO:0000313|EMBL:POS81779.1};
RA   Wadl P.A., Mack B.M., Moore G., Beltz S.B.;
RT   "Development of genomic resources for the powdery mildew, Erysiphe
RT   pulchra.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes cyclization of the linear tetrapyrrole,
CC       hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
CC       {ECO:0000256|RuleBase:RU366031}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hydroxymethylbilane = H2O + uroporphyrinogen III;
CC         Xref=Rhea:RHEA:18965, ChEBI:CHEBI:15377, ChEBI:CHEBI:57308,
CC         ChEBI:CHEBI:57845; EC=4.2.1.75;
CC         Evidence={ECO:0000256|ARBA:ARBA00000783,
CC         ECO:0000256|RuleBase:RU366031};
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 3/4.
CC       {ECO:0000256|ARBA:ARBA00004772, ECO:0000256|RuleBase:RU366031}.
CC   -!- SIMILARITY: Belongs to the uroporphyrinogen-III synthase family.
CC       {ECO:0000256|ARBA:ARBA00008133, ECO:0000256|RuleBase:RU366031}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POS81779.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; PEDP01007994; POS81779.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4PIA4; -.
DR   STRING; 225359.A0A2S4PIA4; -.
DR   UniPathway; UPA00251; UER00320.
DR   Proteomes; UP000237438; Unassembled WGS sequence.
DR   GO; GO:0004418; F:hydroxymethylbilane synthase activity; IEA:InterPro.
DR   GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06578; HemD; 1.
DR   Gene3D; 3.40.50.10090; -; 2.
DR   Gene3D; 3.30.160.40; Porphobilinogen deaminase, C-terminal domain; 1.
DR   InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR   InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR   InterPro; IPR022418; Porphobilinogen_deaminase_C.
DR   InterPro; IPR036803; Porphobilinogen_deaminase_C_sf.
DR   InterPro; IPR039793; UROS/Hem4.
DR   PANTHER; PTHR38042; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   PANTHER; PTHR38042:SF1; UROPORPHYRINOGEN-III SYNTHASE, CHLOROPLASTIC; 1.
DR   Pfam; PF02602; HEM4; 1.
DR   Pfam; PF03900; Porphobil_deamC; 1.
DR   SUPFAM; SSF69618; HemD-like; 1.
DR   SUPFAM; SSF54782; Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU366031};
KW   Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244,
KW   ECO:0000256|RuleBase:RU366031};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237438}.
FT   DOMAIN          1..58
FT                   /note="Porphobilinogen deaminase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03900"
FT   DOMAIN          145..285
FT                   /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT                   synthase"
FT                   /evidence="ECO:0000259|Pfam:PF02602"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:POS81779.1"
FT   NON_TER         294
FT                   /evidence="ECO:0000313|EMBL:POS81779.1"
SQ   SEQUENCE   294 AA;  33062 MW;  A28FB7BA26AFD982 CRC64;
     LAGGCQVPIG SYAEIEGDQI WLRALVGAPD GSTIIRSEGR APLTQAEKLG QRLADDLLCR
     GAYAILNLTR PSLAGEQLVK LLRAYGQSAW HLPLINFVPG IDLPMLAERL TALSHDDLLF
     LFSQHAIYYA NSWLRQQGIT WPVSGLPVSY PPYKNETSEG LLNLPSLASL DGRRALVLRG
     NGGRELLKNT LIQRGVQVEY CECYRRCPIL YDSEEQGRRL LSLGIKTLII TSGEMLQQFY
     TLMPKYSHYY WFMRCRLIVV SERLAIIAYK LGWKNIIVIN IADNDTLCVY CLKI
//
DBGET integrated database retrieval system