ID A0A2S4PQ12_9PEZI Unreviewed; 1069 AA.
AC A0A2S4PQ12;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
DE Flags: Fragment;
GN ORFNames=EPUL_004453 {ECO:0000313|EMBL:POS84125.1};
OS Erysiphe pulchra.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Erysiphales; Erysiphaceae; Erysiphe.
OX NCBI_TaxID=225359 {ECO:0000313|EMBL:POS84125.1, ECO:0000313|Proteomes:UP000237438};
RN [1] {ECO:0000313|EMBL:POS84125.1, ECO:0000313|Proteomes:UP000237438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Cflorida {ECO:0000313|EMBL:POS84125.1};
RA Wadl P.A., Mack B.M., Moore G., Beltz S.B.;
RT "Development of genomic resources for the powdery mildew, Erysiphe
RT pulchra.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271}.
CC -!- SIMILARITY: Belongs to the membrane magnesium transporter (TC 1.A.67)
CC family. {ECO:0000256|ARBA:ARBA00006109}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POS84125.1}.
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DR EMBL; PEDP01001167; POS84125.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4PQ12; -.
DR STRING; 225359.A0A2S4PQ12; -.
DR OrthoDB; 9867at2759; -.
DR Proteomes; UP000237438; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0007127; P:meiosis I; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03281; ABC_MSH5_euk; 1.
DR Gene3D; 1.10.1420.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR018937; MMgT.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR PANTHER; PTHR11361:SF20; MUTS PROTEIN HOMOLOG 5; 1.
DR Pfam; PF10270; MMgT; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237438};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1069
FT /note="DNA mismatch repair proteins mutS family domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015651868"
FT DOMAIN 898..914
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 1069
FT /evidence="ECO:0000313|EMBL:POS84125.1"
SQ SEQUENCE 1069 AA; 119154 MW; 17BFE3BB81051448 CRC64;
MAYISKCLIG LGLLFLAHSC YSAHEHSMLH SVGVAPITQI SKQGVASSAL PSLPTDISVE
TIVAIIVTCL GLVLGTPDLE PIQWRVWAGK IEREGEGRLF HTDGFIKRGY SGNPIKALES
RPGFVDIRRQ RQEFLAWTRN FLRQDADYAL PGPLLLKEKR VSLKLPSTKS PGASTFLLKS
KVNAENTGSI SEVQSHEESD EIHEIFMAVD LRNRETIGCA YYSPREQKLY LVEDVKMTSL
DIIDTLKLQI QPTVILISSK AEEKLESHLS QDARGIDREG EGNDVLGSYV LEYRPASDFS
FDQAKNKLVN LALDQEKESD IVFTTPEDLL GNPVGDQISM QNMGRQGRLM RLSGRIDLES
KVTVSCAGAV LNYISRRRKS EYLPNDQDAL FFFQVRSIEM ITLSDTLFVN ADTFTSLQII
LRENHPNSHM QGPSKSSSGG KESLSVYGLF YHLARTPQGK QKLRRIFLRP TTNLIVINER
LKSIRVLLRP ENSHYLEKVH HNLKMIKDIR TVILHLQKGI SDISGKGNVF RRGVWGSLQN
FAFNVLKIFE AIHEISDTET LDITVRIITE IDAALLNHVG ILITETVDFN ASAELHRTAI
LQGVDAELDS VKRTYDGMDN LLTQVANQLS TSVPEWASQY IENCIFFPQL GFLTVVPLDP
ETGNGKYEGE GVLNDIWERM FVSNDMGYYK NRCMREMDAY FGDMYGKICD REIEIVHELA
VAVLKHENVL ITASDLCGEL DCLVALALGA RKYRFCEPQI TPENIISIEG GRHPLQELTV
PAYISNNCSI AGGTGKNDQT EKLVKLPENS VQKSKGPSML IMTGPNYSGK SAYLKQNALI
VYLAHIGSFV PAENATIGLT DKIMTRINSR ESVSRNQSAF MIDLQQVSLA LTLSTHRTLI
VIDEFGKGTN ATDGAGLCCG VFEYLLSLGS ERPKVLAATH FHEIFENGYL CDRPELAFGH
MEVRVDSESE SGEDQITYLY RFLLGRSISS FGTCCALMNG IDPIIVKRAE ELILCAARGE
DLTAICATIS ADEIQELESA ETIGRRFLEQ DFSDLDPQQS DLQLLTHIK
//
