ID   A0A2S4PVF2_9PEZI        Unreviewed;       724 AA.
AC   A0A2S4PVF2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=ELMO domain-containing protein {ECO:0000259|PROSITE:PS51335};
GN   ORFNames=EPUL_002761 {ECO:0000313|EMBL:POS86006.1};
OS   Erysiphe pulchra.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Erysiphales; Erysiphaceae; Erysiphe.
OX   NCBI_TaxID=225359 {ECO:0000313|EMBL:POS86006.1, ECO:0000313|Proteomes:UP000237438};
RN   [1] {ECO:0000313|EMBL:POS86006.1, ECO:0000313|Proteomes:UP000237438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Cflorida {ECO:0000313|EMBL:POS86006.1};
RA   Wadl P.A., Mack B.M., Moore G., Beltz S.B.;
RT   "Development of genomic resources for the powdery mildew, Erysiphe
RT   pulchra.";
RL   Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC       phagocytosis of apoptotic cells and cell motility. Acts in association
CC       with DOCK1 and CRK. Was initially proposed to be required in complex
CC       with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC       nucleotide exchange factor (GEF) activity of DOCK1.
CC       {ECO:0000256|ARBA:ARBA00024863}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POS86006.1}.
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DR   EMBL; PEDP01000434; POS86006.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4PVF2; -.
DR   STRING; 225359.A0A2S4PVF2; -.
DR   OrthoDB; 1473500at2759; -.
DR   Proteomes; UP000237438; Unassembled WGS sequence.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024574; ELMO_ARM.
DR   InterPro; IPR006816; ELMO_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR12771:SF56; CED-12; 1.
DR   PANTHER; PTHR12771; ENGULFMENT AND CELL MOTILITY; 1.
DR   Pfam; PF11841; ELMO_ARM; 1.
DR   Pfam; PF04727; ELMO_CED12; 1.
DR   Pfam; PF16457; PH_12; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS51335; ELMO; 1.
PE   4: Predicted;
KW   Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW   Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237438};
KW   SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT   DOMAIN          257..445
FT                   /note="ELMO"
FT                   /evidence="ECO:0000259|PROSITE:PS51335"
FT   REGION          274..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          590..610
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        286..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   724 AA;  81970 MW;  E534083C9839A00E CRC64;
     MNQADIPELL TRLQSNEDST RKLAVFKLQA SINDPSIADV FISTGGLKIL RQLIMTASGN
     TLAYALAALS RLLEVEMGWE IFESNGAEAL VERLVGLIVT HPLVNILRGA MSILVAVVSH
     SQNSRESSKV PGVFGFRALK PAVAVYPQFF EMVVSQLKSA DHLLCSSALM LLNALLRDGL
     SRVEPKEKNS GELSKAGEKW PQLINKLQDL GIVQAAYDLM QSSSLQDMTH SLLEFQAVSK
     LILKKRRDTE VQLENSEHVG ILERIYISSQ KKSKNEAQSK IKQTENSSTD GKKKINKENP
     DKWTNLGFQT ENLSWDFEQT GFLGLMDLAY FVAKDEDGFQ KLLQEQETRP FNERCPIARA
     SLSVTRTLYD HFEIDRSDLE DIKNYRALDG MKNYADFFRP FILQWSRIHR KALSSFIILW
     KQVGAEQEEF GKVVELLRIL VDKVLSGVAR TKDIKEIEEE IAGFDYRQLR KIQMEILNNA
     FEDEWELHLT QIREELRNEA LQFMKEQRIR SLLNGAWFHR TETNSSIPES PNETTYSAAW
     QYVKLSYDKR YLHYGDFDSQ AIKNPPLDIL SQKIDLENIS SVDSNTSLCG NEDSSAYTPT
     TTVTARPSED PSTITGITIR CFDTIQNGDQ CNLDTSNGSI PEKIVLVLVP INKNLASSWL
     DGLLMLLNQA PITSETSKLV NFICDYGLKI RLLNVRMDDF LDPLDGAGII PSREGLDDDY
     FYEM
//