ID   A0A2S4V674_9BASI        Unreviewed;      1128 AA.
AC   A0A2S4V674;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=PSHT_04358 {ECO:0000313|EMBL:POW19746.1}, PSTT_10050
GN   {ECO:0000313|EMBL:POW04955.1};
OS   Puccinia striiformis.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX   NCBI_TaxID=27350 {ECO:0000313|EMBL:POW04955.1, ECO:0000313|Proteomes:UP000239156};
RN   [1] {ECO:0000313|Proteomes:UP000238274, ECO:0000313|Proteomes:UP000239156}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=93-210 {ECO:0000313|EMBL:POW04955.1,
RC   ECO:0000313|Proteomes:UP000239156}, and 93TX-2
RC   {ECO:0000313|EMBL:POW19746.1, ECO:0000313|Proteomes:UP000238274};
RA   Xia C.;
RT   "Gene loss provides genomic basis for host adaptation in cereal stripe rust
RT   fungi.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POW04955.1}.
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DR   EMBL; PKSL01000105; POW04955.1; -; Genomic_DNA.
DR   EMBL; PKSM01000044; POW19746.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4V674; -.
DR   VEuPathDB; FungiDB:PSHT_04358; -.
DR   VEuPathDB; FungiDB:PSTT_10050; -.
DR   Proteomes; UP000238274; Unassembled WGS sequence.
DR   Proteomes; UP000239156; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000239156};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          795..1128
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..381
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1096
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1128 AA;  128359 MW;  5B830A4CD01DB6B7 CRC64;
     MYSFTGQTKR RPFINLGGQS NSDKPSEVMR RAKQERLLRE KFKHQQAASA IIQNFWRSRV
     DAGLTKTAMR NRFDQLLSFV FDNIPDVGPA NFALSPDNHL ELTRLILIFY TPHRSDDQRR
     LANWTNQLTS YLSYLQRDDQ LGNSFKRIVP LIIRRILNTL AESPRSEYAL TLLGALKELV
     EDLNRRSDLN ALILMTRTWY WKFCKKFITS FQVTDKSASQ TVALVIELAV SPFQVFPTEQ
     KNDLASIFAS QIFTIPLLPN RLGLQALIQF TANLPFLEII TATNRFIQDL ELEEIIHLLS
     NSLVWGSKKV IHMDQNGFKG YLNTIQLCLD RLPPSLFKKV DNHLANKTLK ATKRHPQQPR
     TRTTPSNEII SSNSHSGTKT NPIMIDEPDG MVEEGSDKKR TIMNVLNSIG PKTLQWLSVL
     VQSDHLSQLC SMSAKYSSSG CQPQLCRLMV SIIYLWPSSK ETILNTLIYM TSSTGPSTNR
     STNQSGGFIK ELWRCYVRPG KISISLRDRK SGGSPQGVLT TLKDPKLIGQ WEDLILLCEL
     YSRYLMSLGD EEFFDDAAEV ASSSFQQAKA SVISTSNRNP LMIDEVITLA GLLRNLAFGL
     YWTEGQADIK NGCVVGTLVS LEYLRSMATR LLQQIYIRDS RRPFCEPDFW SMTSTFDLQS
     FMQTVVYEES HLEEVREDQL QSPAAQLLNQ DPDLDLSNHL SSSNSSSSRG TARARVSQRQ
     LAFISPRLGV LNNIPFVIPF EQRVAIFRTF INSDRHRLGL DSHYQFGENR HKASIRREFV
     SEDGFTHLNN LGFKLKETIE IKFIDSYGLE EAGIDGGGVF KEFLTSLTKE IFDINKGLWL
     VNKNMEIYPN PHSYSKSPVS LEWFTFLGRV IGKALYEGIL IDIDFADFFL NKWLGKQSYL
     DDLGSLDPEL YQGLIFLKHY KGDIETDLSL NFTITNNEFD ESTTIELVPG GSSKSVTVQN
     RINYIDLISN YKLNIQIEEQ CNAFFKGLND LIDLKWLRMF NQIELKSLVG GLDGQDLDID
     DMQANTVYGG WDESHPTIRI FWKVIRKFDN SNQRKLLKFV TSCGRPPLLG FKELRPSFAI
     RSSGTDRSRL PSASTCVNLL KLPEYLNEIE LENKLVYAIN SGAGFDLS
//