ID A0A2S4W503_9BASI Unreviewed; 371 AA.
AC A0A2S4W503;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=UDP-glucose 4-epimerase {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
DE EC=5.1.3.2 {ECO:0000256|ARBA:ARBA00013189, ECO:0000256|RuleBase:RU366046};
GN ORFNames=PSTT_01048 {ECO:0000313|EMBL:POW16861.1};
OS Puccinia striiformis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=27350 {ECO:0000313|EMBL:POW16861.1, ECO:0000313|Proteomes:UP000239156};
RN [1] {ECO:0000313|EMBL:POW16861.1, ECO:0000313|Proteomes:UP000239156}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=93-210 {ECO:0000313|EMBL:POW16861.1,
RC ECO:0000313|Proteomes:UP000239156};
RA Xia C.;
RT "Gene loss provides genomic basis for host adaptation in cereal stripe rust
RT fungi.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=UDP-alpha-D-glucose = UDP-alpha-D-galactose;
CC Xref=Rhea:RHEA:22168, ChEBI:CHEBI:58885, ChEBI:CHEBI:66914;
CC EC=5.1.3.2; Evidence={ECO:0000256|ARBA:ARBA00000083,
CC ECO:0000256|RuleBase:RU366046};
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911,
CC ECO:0000256|RuleBase:RU366046};
CC -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC {ECO:0000256|ARBA:ARBA00004947, ECO:0000256|RuleBase:RU366046}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU366046}.
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. {ECO:0000256|ARBA:ARBA00007637, ECO:0000256|RuleBase:RU366046}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POW16861.1}.
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DR EMBL; PKSL01000005; POW16861.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4W503; -.
DR VEuPathDB; FungiDB:PSHT_02729; -.
DR VEuPathDB; FungiDB:PSTT_01048; -.
DR UniPathway; UPA00214; -.
DR Proteomes; UP000239156; Unassembled WGS sequence.
DR GO; GO:0003978; F:UDP-glucose 4-epimerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003974; F:UDP-N-acetylglucosamine 4-epimerase activity; IEA:RHEA.
DR GO; GO:0006012; P:galactose metabolic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05247; UDP_G4E_1_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR005886; UDP_G4E.
DR NCBIfam; TIGR01179; galE; 1.
DR PANTHER; PTHR43725; UDP-GLUCOSE 4-EPIMERASE; 1.
DR PANTHER; PTHR43725:SF51; UDP-GLUCOSE 4-EPIMERASE; 1.
DR Pfam; PF16363; GDP_Man_Dehyd; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|RuleBase:RU366046};
KW Isomerase {ECO:0000256|RuleBase:RU366046};
KW NAD {ECO:0000256|RuleBase:RU366046};
KW Reference proteome {ECO:0000313|Proteomes:UP000239156}.
FT DOMAIN 8..358
FT /note="NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF16363"
SQ SEQUENCE 371 AA; 41348 MW; 0A081543BFB40623 CRC64;
MPEPRRTILG YIGSHVLLCC LLTKKYKVIT IDNFHNSFPP AIERVSRIAS DELPKDATEE
DKKYTHITLY KGDITIKSDI ENVFENENVW GVVHIAAHKA VGESGEKPIQ YYENNITATI
NLLDVMNRHD CHHIVYSSSA TVYGAPTTIP IPEITPLQPE SVYGRTKMMS EYIIKDLCDS
EPKKWKAISL RYFNPAGAHP SGLIGEDPVG KPGNLLPLLA QMAVGKIPHD LKVNGNDYPT
RDGCCIRDYI HVMDLAGGHI NALDGLIKES TWNTPCPGFK SAFGTSGGKY KAYNLGKGRG
QSVFEMIEAM RKATGFDYKF EIIGRRSGDV PDLTADPTLA RNELGFDAPR ELDEMCRDLW
NWQSKNPKGY A
//
