ID A0A2S4XR58_9ACTN Unreviewed; 826 AA.
AC A0A2S4XR58;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE Flags: Fragment;
GN ORFNames=C3486_19930 {ECO:0000313|EMBL:POX39047.1};
OS Streptomyces sp. Ru73.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2080748 {ECO:0000313|EMBL:POX39047.1, ECO:0000313|Proteomes:UP000236956};
RN [1] {ECO:0000313|EMBL:POX39047.1, ECO:0000313|Proteomes:UP000236956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ru73 {ECO:0000313|EMBL:POX39047.1,
RC ECO:0000313|Proteomes:UP000236956};
RA Suneja G., Sharma R.;
RT "Genome sequencing of cellulose degrading bacteria.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POX39047.1}.
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DR EMBL; PQSQ01000045; POX39047.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S4XR58; -.
DR OrthoDB; 9810730at2; -.
DR Proteomes; UP000236956; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd06225; HAMP; 2.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 1.20.120.1530; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF18947; HAMP_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00304; HAMP; 2.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR PROSITE; PS50885; HAMP; 2.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:POX39047.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000236956};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..56
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 96..148
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 369..589
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 663..780
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT REGION 595..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..826
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 311..352
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 713
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:POX39047.1"
SQ SEQUENCE 826 AA; 88364 MW; 1B4AD0DD7E9DC957 CRC64;
FMASNLTTQV RNIALVATAV AQGDLSQKID VDARGEILEL KTTLNTMVDT LSSFASEVTR
VAREVGSEGQ LGGQARVEGV YGTWKSLTTS VNELASNLTT QVRAIAEVTS AVASGDMTRN
VTVEARGEVA KLKNNINMMV SNLRETTRAK DWLDANLARL AGLMQGHRDL VEVADLILRE
LTPLVNAQYG AFFLASAETD ELRLDFIAGY GSAHDASIDT PGSHGHGLVR QAAIEKKRIL
VEDVPSDYIK VDSGLGEAAP TTVVIIPVLF EDQTLGVIEL ASFSRFSDVH LAFFDQFVNT
IGVAINTIVA NSRTESLLSE SQRLARQLQE RTGELQRRQA ELQRSNAALE EKAALLASSS
RYKTEFLANM SHELRNPLNS LLILAQMLID NEHGHLSRHE VESAAMIHRS GSELLQLIND
ILDLSKIEAG RMDVFPSRVP INKLLSYVHD TFRPLTLDRG LAFEVSVTDA VPKELYSDEK
RIKQVLRNLL SNALKFTSKG KIDLSVDQAG DETVTFTVTD TGIGIAPEKL PVIFEAFQQA
DGTTNRKYGG TGLGLSISRE IAGLLGGALT AESEPGVGST FVFRIPVRCR GTADALDQPS
AAPAVPGVPA GGPEGAAAGT PPEPPRPLVP VPAGASDDVS WPAVSNVEQW AKGATGELLS
GAQALVVDDD IRNAFALTNV LSRVGMRVVY AEHGREAIEM LGKNPGIDFV LMDIMMPEMD
GYETIRAIRR TPRYADLPVV VLTAKAMPGD REKSLETGAN DYLPKPLDVD RLLNVAVDLL
SKYRSSAPAP EGAAVPSPDG DAPAAEGGGA GPAEAADADG GEDRSP
//
