ID   A0A2S4Y4N6_9ACTN        Unreviewed;       780 AA.
AC   A0A2S4Y4N6;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=MMPL family transporter {ECO:0000313|EMBL:POX43758.1};
GN   ORFNames=C3488_35285 {ECO:0000313|EMBL:POX43758.1};
OS   Streptomyces sp. Ru72.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2080747 {ECO:0000313|EMBL:POX43758.1, ECO:0000313|Proteomes:UP000237426};
RN   [1] {ECO:0000313|EMBL:POX43758.1, ECO:0000313|Proteomes:UP000237426}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ru72 {ECO:0000313|EMBL:POX43758.1,
RC   ECO:0000313|Proteomes:UP000237426};
RA   Suneja G., Sharma R.;
RT   "Genome sequencing of cellulose degrading bacteria.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POX43758.1}.
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DR   EMBL; PQSR01000130; POX43758.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4Y4N6; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000237426; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237426};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        294..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        320..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        568..592
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        599..621
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        633..651
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        672..693
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        705..731
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          215..348
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          759..780
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   780 AA;  81021 MW;  A1448D6DED96418D CRC64;
     MPSRLFSPVS VPLASQTRFS TLRRNSMKNP ISLSVRRPRT VIAAWLLLLA LAAPFALQLE
     GALKAGGFSN PRGESVHAQR TLEQAFKEAP NSLLVVLHDP SGSVQGAVTQ ARQAVQRPGV
     TAVTDERTHP EWVSKDGRTT FLQVGFTGDS TTVQNVVPDV RRDVRAAVGK GVEVDVTGGP
     ALDYALNVHS KEDVTRAEMI AFPVLFVVLL LVFRSVVAMV VPLVLAGFTL AVTQALGYGM
     AQLTDINSLF GNIVSMVGLA VAVDYSLFII KRFREELAEG RDAPAAVERS MRTVGHSVLF
     SGLAVVVALS ALFIPRAMSF TSIALGGTAV AVVAVAMAMT LLPAVLSLLG HRINAGTLRR
     RGKAAAAADA APQPGRFPGR PGLVLAALLV GFTALAWPAT QLTLRVPVAS ASILPSGDSA
     RVGMERIKKD IGIRAMFPVQ VVLTADAKDS SALLKTATSV AEHARSANGA DGVQAVSTLG
     LPAGSLPQAL ADGTGLDAAG RAAVGQLWAK VGDTVVTRVL VTPDADPDSS AAHHLVSDLR
     SHLKSETGPG VTAELAGATA TGSDFDSLVL HSVPLVVLTV ALLSFLILFL AFRSTVLPLL
     ALAFNLLVVG ASLGFLALVA SGTDHSINSV TPLMLFAVMF GLSMDYMVIM IGRMREMRLD
     GAAHRDAVLG GLARTAGLVN GAAAIMVAVF VSFTSAQISI VRELGISLAA AVVLDAIVIR
     RLVMPATLLL LGDRVWGRKH RSAAPAADSV TGTAAEEAAG ATTVLPSTGP ELPASGSLLR
//