ID   A0A2S4Z7R2_9ACTN        Unreviewed;       789 AA.
AC   A0A2S4Z7R2;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=Trehalose 6-phosphate phosphorylase {ECO:0000313|EMBL:POX57266.1};
GN   ORFNames=C3489_00690 {ECO:0000313|EMBL:POX57266.1};
OS   Streptomyces sp. Ru71.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2080746 {ECO:0000313|EMBL:POX57266.1, ECO:0000313|Proteomes:UP000237414};
RN   [1] {ECO:0000313|EMBL:POX57266.1, ECO:0000313|Proteomes:UP000237414}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ru71 {ECO:0000313|EMBL:POX57266.1,
RC   ECO:0000313|Proteomes:UP000237414};
RA   Suneja G., Sharma R.;
RT   "Genome sequencing of cellulose degrading bacteria.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC       {ECO:0000256|ARBA:ARBA00006768}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:POX57266.1}.
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DR   EMBL; PQSS01000001; POX57266.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S4Z7R2; -.
DR   OrthoDB; 9816160at2; -.
DR   Proteomes; UP000237414; Unassembled WGS sequence.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR005194; Glyco_hydro_65_C.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   InterPro; IPR005196; Glyco_hydro_65_N.
DR   InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR   InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR   PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR   PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR   Pfam; PF03633; Glyco_hydro_65C; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   Pfam; PF03636; Glyco_hydro_65N; 1.
DR   PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237414};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          8..256
FT                   /note="Glycoside hydrolase family 65 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03636"
FT   DOMAIN          308..703
FT                   /note="Glycoside hydrolase family 65 central catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF03632"
FT   DOMAIN          713..775
FT                   /note="Glycoside hydrolase family 65 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03633"
FT   ACT_SITE        484
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT   BINDING         345..346
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT   BINDING         604..605
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ   SEQUENCE   789 AA;  88139 MW;  0F91C895FCA92A11 CRC64;
     MAAWTWEYEG YAPVDERLRE SLCTLGNGRF ATRGALPECD ADDIHYPGTY AAGCYDRLTS
     VVADRRVENE DMVNLPNWLP VRFGPAGGEW LTPDTAPVLD HHLTLRLESG LLERITSYGL
     DAERTLTVRQ ERLVHMADPH LAALRTAFTV DGAATDLEVE AALDGGVTNA GVQRYRGLEG
     HHLTHVHTGT AGPDTVWLRC RTRTSDIRIA LAARLTADAP VTDAHERPRA VQRLRLRLEP
     GRTRTVDKTV ALHTSRDPAI SDPLQAAVDR VTAAPGFGEL LESHRTAWAQ LWRRAEIDVP
     GEEGAILRLH LFHVLQTLSP HTADLDVGVP ARGLHGEAYR GHVFWDELFV LPYLNLHFPE
     VSHGLLLYRH RRLDRARAAA RAIGRRGALY PWQSGSDGRE ETQRLHLNPR SGRWLPDHTH
     LQHHVGSAVA YNVWQYCEAS GDAEFLHTKG AEMLLQIARF WADSAVWDEH LGRHRIRGVV
     GPDEYHDAYP GAAAPGLDDN AYTNVTAAWV LARTLRVLRD LPEPRRRELF ERTAVDPGEL
     ERWEDVSRTL HVPFHDGVIS QFDGYGDLAE LDWDGYRKRY GDIRRLDRIL EAEGDTVNRY
     RASKQADVLM LGYLFSPAEL GWLLGRLGHR LDAGTWQRTV DHYLARTTHG STLSGLVHGW
     VLARARRAEA WTFCLEALRS DVADLQGGTT GEGVHLGAMA GTLDLVQRGL TGLETREGAL
     WLDPVPLPEL SSYGFSLRYQ GHWGVRVRLE SGRLEIAVPP SDLPPIDVRL PDRTIGVQPG
     RTCRLPLSG
//