ID A0A2S5A6G3_9FLAO Unreviewed; 797 AA.
AC A0A2S5A6G3;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Tyrosine protein kinase {ECO:0000313|EMBL:POY38106.1};
GN ORFNames=C3L50_12595 {ECO:0000313|EMBL:POY38106.1};
OS Flavobacterium alvei.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Flavobacterium.
OX NCBI_TaxID=2080416 {ECO:0000313|EMBL:POY38106.1, ECO:0000313|Proteomes:UP000237310};
RN [1] {ECO:0000313|EMBL:POY38106.1, ECO:0000313|Proteomes:UP000237310}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR-AY {ECO:0000313|EMBL:POY38106.1,
RC ECO:0000313|Proteomes:UP000237310};
RA Gaut B.S., Morton B.R., Clegg M.T., Duvall M.R.;
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POY38106.1}.
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DR EMBL; PQVG01000007; POY38106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S5A6G3; -.
DR OrthoDB; 9794577at2; -.
DR Proteomes; UP000237310; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:POY38106.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237310};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 28..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..109
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 454..521
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 591..734
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
SQ SEQUENCE 797 AA; 89514 MW; 8039286C9DB69720 CRC64;
MKDHFMSEEY QEDDIHLRAI LEKYLIHWYW FVLGALLCLS VAYVYLRYTI PQYQASTTIL
VKDDKKGGML SELSAFADMG LGGGMKSNLD NEVEILKSRT LIERTVRELK LNVSLTRKGN
VVDAELYQEA PIRVYFLNTK PSFYTELMQF EFVKLTANSF ELTNKTEGET SKLLSSKKEF
RYGEVIPTKN GDLIITKGIT EKALNRYTER SINIIVTPLE NVVASFQARL NINPISKTSS
VVEISVVDPV IAKAEVFLDN LIRIYNEEAA ADKSYISENT SKFVANRLLL ITQELDGVEQ
DVQHFKTNNK LTDIETEAKL FIEGSTEYNK KRVEIEIQLN MVASMLDFIK KSTNSDLLPT
NMISAQGDAP KLMDSYNELV LERNRILKSA TVANPTVIKL DQQLASLKSN IVESLGRLQS
NLNIQKRDLK GQEGLLDGKI GAIPVQERQF RVIARQQKVK EELYLYLLQK REETAISLAA
TEPNARVIDA AKAAKVPVSP KKRIIYLAAL LLGLLIPLGI LYVIELLDTK VKNRLDITDK
FNIPFLGDVP RSDTPNEIIS TTSRTSAAEA LRIVRTNLDF MLNQVPDGSA KTIFMTSTIP
GEGKTFISVN LAGIFALSGK KVLLIGMDIR SPKLNEYIGL PSLKGLTDYL STKNAAIGDY
INRLNNFEAF DVLLAGSIPP NPTEMLMSKK LDALFSQLKT EYDYILVDTA PVSLVSDTLI
VAKHADTFVY VVRANHLDKR MLVVPNGMHR EKKLPNMAFL LNDTDVTKGY GYGGYGYGYG
YGNVVAKKPW YKRIFMK
//
