ID A0A2S5B4E2_9BASI Unreviewed; 1476 AA.
AC A0A2S5B4E2;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN ORFNames=BMF94_5406 {ECO:0000313|EMBL:POY71581.1};
OS Rhodotorula taiwanensis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=741276 {ECO:0000313|EMBL:POY71581.1, ECO:0000313|Proteomes:UP000237144};
RN [1] {ECO:0000313|EMBL:POY71581.1, ECO:0000313|Proteomes:UP000237144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD1149 {ECO:0000313|EMBL:POY71581.1,
RC ECO:0000313|Proteomes:UP000237144};
RX PubMed=29375494;
RA Tkavc R., Matrosova V.Y., Grichenko O.E., Gostincar C., Volpe R.P.,
RA Klimenkova P., Gaidamakova E.K., Zhou C.E., Stewart B.J., Lyman M.G.,
RA Malfatti S.A., Rubinfeld B., Courtot M., Singh J., Dalgard C.L.,
RA Hamilton T., Frey K.G., Gunde-Cimerman N., Dugan L., Daly M.J.;
RT "Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites:
RT Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.";
RL Front. Microbiol. 8:2528-2528(2018).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POY71581.1}.
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DR EMBL; PJQD01000079; POY71581.1; -; Genomic_DNA.
DR STRING; 741276.A0A2S5B4E2; -.
DR OrthoDB; 5476208at2759; -.
DR Proteomes; UP000237144; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000237144}.
FT DOMAIN 494..635
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1162..1476
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 223..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 656..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 740..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1025..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 227..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..405
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1053
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1476 AA; 159561 MW; 5C86AC72673B5075 CRC64;
MTEERPHASA AGPSADPVPA TAFVETTNET AVRAFVERVA QVNGSLNPGD LVQTSVDAKG
RTLYRLSLAG LDDPEPVQNA HLRSPKTPFA LPFTRPARSP LARSADRPRP PTERTSLRPT
RSIPLLRVEA AGNGQTASEI DAVAPGATGQ RYLRRVGSSP LLNGSGEAST PRDMRALEAF
PVGRVTKARG DGTGDIIGRL LTWRTAKPAA PTSRADDVAM DLKRQDGSQP DGSQSGLLTS
GASPADTGPH VPSYEIAKAA DPGREHPTAR PRTRHSHAQQ PFGTGVRLPP VSSSGSLQGS
QVFASVPFAT EAPTLPFMRE VSSSDSIRTA KADAHASHAP IELTAVPAVR SYDPAIFDAF
HPGTASGVAF PTEPSTQPHR LPFGHHGRAD STRSVASHRS DATESSAHEI TLVPTAGDDP
RYVLWGEKSK KSPATLASAS ATPTRMRRRA SPASSATDSP VSADRFPHSD SRSSPASSVR
QSVGSTVEDI RVPRERVLMA ATVERLVAEL TSQIAPDLLA DFFLTFRSYL APLELMHLLL
TRFEWAMKSD PPLPPERDAR PALASIDDAE NAALRRIVRV RTFVVLRYWL LNHFMQDFYP
SRDLRTTLTS WLNESAREER FRSSPRDLRL IKALKRTVRK CKEAYISGRA QRDAAAAGRS
PVLGTAEDGG DEDRDVDLAV APDRPPQQSL LSSGQDILAP SEPCADATAV DGGLKPPGPI
ARRLSDAMST LGRIKRKLAA VSAKQTRRSA ATIPSPEPSL RDGTEGSSAD LLRHEDRLHS
YLRQLGLELA SKPNEENDES AAEISPSNVA SECTPASIRE AAIPPFDATA PAAVDGHVVH
LGQASTSPAT GLGILARDEE LQPTGLDICG GPAFHTTPAT ETPSFSLLPG LFGPLVDSAR
PASVRVELDD LSDSSDDDDD DVIEAKRVMK RLPPARFLEA QTEQVSSADE LRSRAVGVST
PEAASRTYSA LFVDDEEGYE DGELVTVIPN FILDGLDDSD EENGEGGVEA ALRRLEGIVD
DARERRHAAR VQQQMEKSSK LEEERRQREE GAAVLPSDDS TTTLASDAAS PVESVDRDLL
PAMHGALNTT RGPPELPTTT TEQSVVPRID VELAAGRDAQ APSPGRANLT NRLFGQRATS
AIATPRALSP QSLHRAFVMW HRTDVIVQHF TLIERDLLRM LSYQELVGGN WQRRPDKIDV
LDWETYVKER RRLALAAAER GETTGSAVQD LLARFNLTAN WVASEILLTA SLDERVLVIS
KFIRLAFKSY CLHNLQTVMQ FVHGLLHPDV ARLHKTWGRV PAWEMRKLDS MKDLCGQTGS
FGLLSAHMRA AALGRASQQL HKASFAPGNT GGSQACLPFV GLLLHDVSRT AELPTLLDPT
APDTAASVDS SGRLLAPAQP AAFDDHPPLP ASTPLAPLVN VHQFRRLAET VRTLQTFQEL
SKQYTFKPVS AIYLRCLKLR VLDGHILHEL SLRLEP
//
