ID A0A2S5B9S0_9BASI Unreviewed; 4685 AA.
AC A0A2S5B9S0;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=BMF94_3453 {ECO:0000313|EMBL:POY73516.1};
OS Rhodotorula taiwanensis.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=741276 {ECO:0000313|EMBL:POY73516.1, ECO:0000313|Proteomes:UP000237144};
RN [1] {ECO:0000313|EMBL:POY73516.1, ECO:0000313|Proteomes:UP000237144}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MD1149 {ECO:0000313|EMBL:POY73516.1,
RC ECO:0000313|Proteomes:UP000237144};
RX PubMed=29375494;
RA Tkavc R., Matrosova V.Y., Grichenko O.E., Gostincar C., Volpe R.P.,
RA Klimenkova P., Gaidamakova E.K., Zhou C.E., Stewart B.J., Lyman M.G.,
RA Malfatti S.A., Rubinfeld B., Courtot M., Singh J., Dalgard C.L.,
RA Hamilton T., Frey K.G., Gunde-Cimerman N., Dugan L., Daly M.J.;
RT "Prospects for Fungal Bioremediation of Acidic Radioactive Waste Sites:
RT Characterization and Genome Sequence of Rhodotorula taiwanensis MD1149.";
RL Front. Microbiol. 8:2528-2528(2018).
CC -!- SUBUNIT: Consists of at least two heavy chains and a number of
CC intermediate and light chains. {ECO:0000256|ARBA:ARBA00011655}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:POY73516.1}.
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DR EMBL; PJQD01000036; POY73516.1; -; Genomic_DNA.
DR STRING; 741276.A0A2S5B9S0; -.
DR OrthoDB; 312195at2759; -.
DR Proteomes; UP000237144; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 2.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 1.20.920.60; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10676:SF314; CYTOPLASMIC DYNEIN 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR10676; DYNEIN HEAVY CHAIN FAMILY PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000237144}.
FT DOMAIN 1962..2116
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2644..2799
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2986..3152
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 997..1020
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3481..3529
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 997..1012
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4685 AA; 522747 MW; C635AF946C702DE2 CRC64;
MDDRGGSDPP GRDGGDEVVG RSFDATLTNN TLASTTAQPA FDLPAFESYL LQLLPLVIQA
APRDLDALFR GSDFAERASR WAADPTAGAL YIVKQRAEPT ADPEQGSPAF TYSLSTTLSY
SPTQSATLAL IKHVPTLDNT VPIPAQLHFL NLFGPASFGS GASATGSGAG TAAATAASGS
AVYEGLHRLL HYGVAPAFEA YVESKARKED AGRGVDDGKD ADAKMGIPVT KKKFAELELS
LLHLQQNVEI PQVVLSIHPV VQAAVAKAES AGVRPSTDLI DPALFSDATF LNRLQGEVNS
WVKEVQTVTK LSRDVASGTA SQEINFWLGM EKALEGIEQQ LKSDPVQLSL DILKHAKRFH
ATVSFIADTG LNDAFKIVHD YNVLMKDFPL NELLAATDLN KLAESVNLVF SHLNKKLKLS
PYPVRRALPL VEAISRDLNS QLLRVLSSQR LTYLDYPLFE RAMAACHAVF LAWDDSFKEF
TNVAREVTRK RSEKFIPIKI SPVHAKLQER VLYFRQFRKQ HHQLQVMVGP LGAEARKAAG
DGTVAQHEDA LDAESRREWA TTLGDIDMEA EVRQAYESVK EVNILDVSTE GTDYWIAAET
AYNERVARVE NHIISRLRDR LGSAKNANEM FRVFSKFNAL FVRPKIRGAI AEYQTQLIDS
VKDDIRALQD KFKLGFQSSE AHAMAQLRDQ PPVSGAITWA KQIERQLYHY MKRVEDVLGK
EWSHYAEGQR LQTESQSFRE KLNPRPIYEA WLADINRRNL QIGGRLFSIA KSRQQNGDLQ
LVVNFDAQII SLFKEVRNLL WLGYQVPHTL SNLAKDAKRV YPYAVSLMET VRTYSQTVAK
LEANPEIAPL VATVHKKAQD QLVKGFGYRW DHFVNTFDTR ATPYDAPGGL SSSGTKHTHY
VRELASIVSD LQDRTDYLVD LYADAARTVD ELGTCAYDRD VFSSRLAALQ KIIDTLNLEG
YANLEHWVAA LDAKVEDKLR ERIRAVVAAW SRDFTDASES QSQGQPTRAA TRAGPTSEGD
VGAAKLTHEV RIQDQVIFLD PPLERARATW YRQLQDRLTV VCSLHRIQTS RYEVGLRISG
ESTESAPNYS TLLLSFVDGT LERPFELVEQ KLCEVGLYVD RWLQFQSLWD LEAEDVYARL
GDQLSQWQQL LLEIRKTRST FDNSELRRSF GVLEIDYEQV QAKVTAKYDT WQRELVARFG
VKLGAAMKET LAGISRARHE LEQHSIETSS TSATVAFITF VQDVKRRAKQ WEAEVAVYSS
GQKTLERQRY HFPPDWTYLD HLGNEWGALN QILARKNASI QEQLAGLQLK IVAEDKVLRG
RIDDAIAAWD ADKPIQGSLR ADEAMNAISG FELRIGSLRE QHVLLNRAKE SLDLEATADT
RLDPIFEELR DLKAVWTALS GVWSQVTEMR EALWSSIQPR KVRQQLDSLL ASTREMPSRM
RQYAAFEHMQ DILRGYIKSN ALLGDLRSEA LRDRHWRQLY KVLRVAGAYS PSTLTLGGVW
DLDLKRNETI IKEVVTQAQG EMALEEFLKQ VKETWSSYTL DLVNYQNKTR LIRGWDDIFA
KCSENVNSLT AMKHSPYYKV FEEEASSWED RLNRVHSLFD VWIDVQRQWV YLEGIFTGSA
DIKHLLPVET QRFNNINTEF LALMKKVAKS PFVLDVLNLP GVQKGLERLA DLLAKIQKAL
GEYLERERQS FPRFYFVGDE DLLEIIGNSK DIPRVGKFLK KMFAGLSSLV LDGDESKIEG
MASRDGEIVP FATPIVLSDY PKINDWLARL EQTMKESLAR TLRQAYADLV AFFASPEALD
SARLLAWVAQ YPAQIGVLAV QVAWTSLVED TLATGASLEE QALPVVLRSL DTLASAVLGD
MPAIERRKCE HLITELVHER DVIRRLVHAS IRSANDFDWL YHMRFYLDTS RDKLLEQLEV
RMASATFSYG FEYLGVPDRL VQTPLTDRCY LTLTQALEAR LGGSPFGPAG TGKTESVKAL
GVALGRFVLV FCCDESFDFQ AMGRIFVGLC QVGAWGCFDE FNRLEERILS AVSQQIQSIQ
LGLAASAADP KHEIELVGRR LHFHHEQVLL PFAPRGPGEQ PLTSSSATVN PGYAGRSNLP
DNLKKLFRSI AMTRPDRELI AQVMLFSQGF RSAETLASKV VPFFNLCAEQ LSSQPHYDFG
LRALKAVLVS AGQLKRGGPQ APGSASSDGS LEVAEQELII RSVRETIVPK LVAADVPTLT
ELLADVFPGV AYKPVDLEDL IRHVQDICAE QHLVAGQDWL AKVVQLYQIQ NIQHGVMMVG
STATGKSTAW RTLLLAVERL TGTEGVSYVI DPKAISKDAL YGTLDPTTRE WNDGLFTAIL
RKIVDDVRGE SSRTHWIVFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLG LPSNVRILFE
VESLRSATLA TVSRCGMVWF SEDTVTAPML CRHYLDRLQS ASVAAESESV DGGVAAGGFG
ADDDLVALAT QRALTVALEP YFAADGLVLR ALSRAADFEH IMTFGVSRAL TTLFSLCNKA
IRSVLEYNQQ HSDFPLSAEQ VETFVLKRLL LAIVWSFVGD STLGTRAAMG DFLRSASGLE
FPQLSLGDSL IDFDVHVATG AWTAWQDAVP TIDIETQAVT ASDVVIPTVD TARHEDILYA
WLSEHKPLLL CGPPGSGKTM TLFSALRKLP DLEVVGLNFS SATTPELILK TFEQHCEYRK
TSNGVVLAPS QIGRWLVLFC DEINLPAPDA YGTQRVISFL RQLVEHGGFW RTSDRAWVKL
ENIQFVGACN PPTDPGRVPL SERFLRHAPL IMVDYPGELS LKQIYGTFTR AMLKVVPPLR
GFAEPLTNAM VDFYLASQRR FTADQQAHYI YSPRELTRWV RGIFEAIKPL DALSVEGLVR
IWAHEALRLF QDRLVAEDER QWTEGQIDEV ATRHFPTLDK AVALARPILY SNWLSRHYVP
VDREELREYA KARLRVFYEE ELDVPLVLFN DVLDHVLRID RVFRQVQGHL LLIGVSGAGK
TTLSRFVAWM NGLSVFQIKV HNKYTAEDFD DDLRAVLRRA GCKGEKIAFI MDESNVLDPG
FLERMNTLLA NAEVPGLFEG DEHAALLTAC REGAQRDGVM LDTPDELYRW FTKNVAKNLH
VVFTMNPPAG GLAGRAATSP ALLNRCVLDW FGDWSDQAFF QVGQEFTAAL DLDTAQYEAP
SNFPVAYRQL QLPPVHRAAV VNALVHVHQT MYATNARLSR RQGRTNHATP RHYLEFVNQY
VRLVAEKRDA LEEQQLHVNV GLEKLRDTVV QVDRLREGLA AKRIQLEAKD AEANEKLRRM
VADQQDAEQK KLASLEMSKA LEAQQAEIAQ RREVVMYELA DAEPAVEDAQ AAVSNIKKQQ
LTEVRSMANP PEAVKLSMEA VCILLGHRIE GWKSVQAILR SDSFIASIVN YDTAYSLTPE
LRKRMRDDYL SRPTFNFETV NRASKACGPL VKWVFAQVNY SDILDKVGPL RDEVQALEDQ
AETTMHQADA LSSMIAELEA RIAAYKDEYA ALISETQAIK AEMDRVEQRV GRSITLLANL
ASENERWEAG SKTFEQQMST IAGDALLSAA YTAYAGYFDQ SYRQTMWEGW SAHLIDAGIH
FKADLSLVEY LSSAEERLTW TSHALPADNL CLENAIILRQ SERYPLLVDP AGQAATFLTE
HFRDRKIAVT SFLDEAFLKS LESALRFGTP LLINDVEYLD PILNAVLNKE LRRAGGRVLI
RLGNQDIDFS PAFTLFLATR DPSADIAADL NSRVTLVNFS ITRASLQTQS LAQVLKVERP
EIDRKRSDLM RLQGEFRARL LHLEKSLLAA LNASEGNILD DDTVIDTLET LQKEATDVAA
KVAETDTVMA EIESVTSQYL PLAKASSDTF FVLDELRIIN HFYQFSLRFF LDTFEAVLVA
NPALDGVTDA QKRLDVLLDS FFLAIYRRAS RSLLHADHLT LAVLLSQIKL RANGNGALED
EFAFLLEGGP SGGAREASET PQWLGPPRLA RLRALESLAS FGPVRGSLEA RAADWQRCLE
SDVPETSIPP IWSGLDSTTA ALRNALVVKC FRPDRLVPAL TIFVNAAFDK DVVLEAAYAF
GRVVLEETAA TSPLCLVSVP GYDASYRVDD LVRATSARCT SVAMGSAEGV TLAEQAIASA
ARTGAWVLLK NVHLAPVWLG QLEKRLQTLG PNRAFRLFLT MEATPSIPAN ILRQGRVFMN
EPPPGVRANL LDSLATMATN RVTTGPAEKA RLYFLLAWFH AVVQERLRYA PLGWTKGIEF
NDADLKSATQ TIDTWLAIAA QGKANVDPAS IPWKAIRLLL RETVYGGKID TLQDQSMLDA
FVERLFSPKA YDLDFVLVPA EGPDRPRVVA PDATTVDQFI EWAQGLPEQE PPSYLALPVS
AERVISTEQG TALIGRLLKL RTLDDDETFA KDVQVKRERQ QPAWMLSLQR SCEDWLTALP
EVGPTVEASF SGDADALRRF YLREVAVAQS VLPLVRHQLR LLAQVCQGEV KQTNDLRALL
ADLVKGTVPS AWRKYRCREL PVAAWVLDLA ERLSQLNRLV KNAVPAAEPV NLGLLFNPHG
FVTASRQTVA HKLEASLEEL ELDVRLGRGA DSDASFPLQG LVLAGAELTS DGLRLNDGSP
VALEQSSLVW LRKREQRPTH RLVAIPCFLD ATRADALFDV RVQVADDVDP TMVVQRAVAI
VAASD
//
