ID   A0A2S5G937_9BACL        Unreviewed;       378 AA.
AC   A0A2S5G937;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Glutathione-dependent formaldehyde dehydrogenase {ECO:0000313|EMBL:PPA69431.1};
GN   ORFNames=C4B60_16740 {ECO:0000313|EMBL:PPA69431.1};
OS   Jeotgalibacillus proteolyticus.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Jeotgalibacillus.
OX   NCBI_TaxID=2082395 {ECO:0000313|EMBL:PPA69431.1, ECO:0000313|Proteomes:UP000239047};
RN   [1] {ECO:0000313|EMBL:PPA69431.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=22-7 {ECO:0000313|EMBL:PPA69431.1};
RA   Li Y.;
RT   "Jeotgalibacillus proteolyticum sp. nov. a protease producing bacterium
RT   isolated from ocean sediments of Laizhou Bay.";
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU361277}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPA69431.1}.
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DR   EMBL; PREZ01000006; PPA69431.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S5G937; -.
DR   OrthoDB; 9769198at2; -.
DR   Proteomes; UP000239047; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08283; FDH_like_1; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR42813:SF2; DEHYDROGENASE, ZINC-CONTAINING, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02810)-RELATED; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          25..140
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          189..261
FT                   /note="Alcohol dehydrogenase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00107"
SQ   SEQUENCE   378 AA;  41349 MW;  98B855DAC6D113B4 CRC64;
     MKAVTYQGIK NVVVKEVPDP KIEKPDDMII KVTSTAICGS DLHLIHGMIP NLQENYVIGH
     EPMGIVEEVG PEVTNLKKGD RVIIPFNIAC GECRYCKDNL ESQCDNSNDN GDMGAYFGYS
     GTTGGYPGGQ AEYLRVPFAN FTHFKIPETC EEPDEKLTVI ADAMTTAFWS VDNAGVKGGD
     TVIVLGCGPV GLFAQKFCWL KGAKRVIAVD YVNYRLQHAK RTNKVEIVNF EDHKNCGEYL
     KEITKGGADV VIDAVGMDAK MTDMEFLASG LKLQSGAFGA FIMATQAVRK GGTIQVTGVY
     GGKYNGFPFG DIMNRNVNIR SGQAPVIHYM PYMFELVTKG TIDPGDVISH VLPLSEAKRG
     YEIFDTKTDD CIKVILKP
//