ID A0A2S5JMC5_9RHOB Unreviewed; 630 AA.
AC A0A2S5JMC5;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|ARBA:ARBA00021975, ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=LV82_00520 {ECO:0000313|EMBL:PPB82582.1};
OS Albidovulum inexpectatum.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Albidovulum.
OX NCBI_TaxID=196587 {ECO:0000313|EMBL:PPB82582.1, ECO:0000313|Proteomes:UP000239736};
RN [1] {ECO:0000313|EMBL:PPB82582.1, ECO:0000313|Proteomes:UP000239736}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 12048 {ECO:0000313|EMBL:PPB82582.1,
RC ECO:0000313|Proteomes:UP000239736};
RA Goeker M.;
RT "Genomic Encyclopedia of Archaeal and Bacterial Type Strains, Phase II
RT (KMG-II): from individual species to whole genera.";
RL Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPB82582.1}.
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DR EMBL; PRDS01000001; PPB82582.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S5JMC5; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000239736; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000239736}.
FT DOMAIN 228..346
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 444..587
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 630 AA; 67830 MW; D80726710F9F242A CRC64;
MTVIDPKISQ NRPVIRQLDE AAINRIAAGE VVERPASAVK ELVENALDAG ARRIEIAQAD
GGKTLIRVTD DGCGMTAQDL PLALSRHATS KIDESDLLNI RSFGFRGEAL PSLGAVGRLR
ITSRAEGHDA AMIEVDGGRM GPVRPAALSR GTVVELRDLF HATPARLKFL RSDRAEAMAI
KDVVLRLAMA EPRVGFVLRD VSGGGEGRVI LRADAEQGEL FDALSRRLRV LLGRDFVENA
IPIEAEREGL RLTGLAALPT YSRGAAVEQF LFVNGRPVRD KLLTGALRAA YSDVLPRDRH
PAAALFIACP PESVDVNVHP AKAEVRFRDP GLARGLLVSA LRHALAEAGH RSATTVAGMT
LGAMRPEPVS ADAPPRIYQM DRPSARALQA SRLAFAPGAA PSQPPTTPHL APELAEASAR
FDAPLPDTDQ DAPDPATACP LGAARAQIHE NYIIAQTATG MVIVDQHAAH ERLVYERLKR
QRAEHGVAAQ ALLIPEVVEL DPTDAALILD HAETLASLGL NVEPFGGGAI AVRETPAILG
EVDAAALIRD ILDELRDEGD SRTLEARIDA VLSRMACHGS VRSGRRMRVE EMNALLREME
RTPLSGQCNH GRPTYVELRL SDIERLFGRT
//
