ID A0A2S5KNG8_9PROT Unreviewed; 1001 AA.
AC A0A2S5KNG8;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=C4K68_15485 {ECO:0000313|EMBL:PPC76361.1};
OS Proteobacteria bacterium 228.
OC Bacteria; Pseudomonadota.
OX NCBI_TaxID=2083153 {ECO:0000313|EMBL:PPC76361.1, ECO:0000313|Proteomes:UP000238196};
RN [1] {ECO:0000313|EMBL:PPC76361.1, ECO:0000313|Proteomes:UP000238196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=228 {ECO:0000313|EMBL:PPC76361.1,
RC ECO:0000313|Proteomes:UP000238196};
RA Krishnan R., Ramesh Kumar N.;
RT "novel marine gammaproteobacteria from coastal saline agro ecosystem.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPC76361.1}.
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DR EMBL; PRLP01000052; PPC76361.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S5KNG8; -.
DR OrthoDB; 5287236at2; -.
DR Proteomes; UP000238196; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd16922; HATPase_EvgS-ArcB-TorS-like; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 3.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR45339; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR PANTHER; PTHR45339:SF1; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08448; PAS_4; 1.
DR Pfam; PF13426; PAS_9; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 3.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000238196};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 17..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 232..304
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 360..405
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 486..526
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 562..613
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 631..853
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 874..991
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 923
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1001 AA; 112937 MW; 874768FE1AD51B82 CRC64;
MVRLKSWFRL TRFESCLMIF GLCSMLVLAG QAIITRIAVE RSKVQIVQSE LTRLSILLPE
MLSPVLREGD VKAARELLQP LLQNDDSGVT AINIVSPFGR EILALGEINQ NVFLRDAMSG
QVSDDGSTIW AHYEIKHQGV LLGTINLGMT TQPFRGEMFI INIAHLLLAL LAVIVLPLLI
RIWRELSNRE QEKTLSLITD WDTKRLEHIQ PQQSYMLSGE RLLTLIELCK RQQERLKDFF
ETTTEALFIL DADGRCQRCN QAARALIGIE SESLIRSQSL IKWFSHTESQ YFDEGFLQRD
IHEALGKSNA FDYEELILHV GKGKPKRVAC HYRPFDVATS TEAGILCCRD ISEQQDIRER
LSLTAQVFES TQEGIMITDV QSRVLAVNKA FTAITGYTAE EIEGQFPDVL SSGIHGQDFY
KDMWDSLTMK GSWQGQIWNK NKEGKLFPEW LSISEIRNQR DEVINYIAVF SDISVLINQE
TEIGNQNRLL RNILDNLNDG VLVLDLNGNI LQANLHAYRV LGLSPDAESI HQWKSGRFIV
ENGELYDEGE PILQALQEHV IWDKEYRLER QGHTAFISIN AKPLYNNSGG HIGALVVLRD
ISQTKQAHAK LLQAVRDAQA ANQAKSDFLA SMSHEIRTPM NGIIGVADIL ADSPGLGEDE
HQLVDIIKSS GELLLSIVND VLDFSKLDAG KLKLSQEPFN VGQLVQASVQ VVEGQARQKG
LECRFEAVDC ADDWVVGDLQ RCRQILVNLL GNAVKFTDKG FVSLSVMQMR KLGQVAWYRF
TVEDSGIGVD ESFRPYLFTR FAQADTSSTR RFGGTGLGLA ICRRLVDQMG GYIDVDSVPG
KGSRFWFEIP LPVREGQREL GRANDDMAFS ASYRILVAED NHVNQAVIAR MLEKMQLQVD
MVANGDEAVR AWQHSRYDLI LMDWRMPILD GLEATRRIRS LEESDQHMII VALTANSSVE
DRQTCIEAGM DDFLPKPVKY EQLRDVLYRH LETGAQTSVQ H
//
