ID A0A2S5T8C4_9BURK Unreviewed; 794 AA.
AC A0A2S5T8C4;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:PPE71221.1};
GN ORFNames=C1702_02025 {ECO:0000313|EMBL:PPE71221.1};
OS Caldimonas thermodepolymerans.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Caldimonas.
OX NCBI_TaxID=215580 {ECO:0000313|EMBL:PPE71221.1, ECO:0000313|Proteomes:UP000239406};
RN [1] {ECO:0000313|EMBL:PPE71221.1, ECO:0000313|Proteomes:UP000239406}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15344 {ECO:0000313|EMBL:PPE71221.1,
RC ECO:0000313|Proteomes:UP000239406};
RA Tang B.;
RT "Reclassifiation of [Polyangium] brachysporum DSM 7029 as Guopingzhaonella
RT breviflexa gen. nov., sp. nov., a member of the family Comamonadaceae.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPE71221.1}.
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DR EMBL; PSNY01000002; PPE71221.1; -; Genomic_DNA.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000239406; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000239406}.
SQ SEQUENCE 794 AA; 86003 MW; E29164BBB71DB8A5 CRC64;
MSRFQVRKVA VLGAGVMGAQ IAAHLVNVKV PVVLFDLPAK EGPKNGIVTK AVEGLKKLKP
APLGVAEDAA LIQQANYEEH LELLKECDLV IEAIAERMDW KLDLYRKVAP HVAPHAIVAS
NTSGLSITKL SEALPEEIKP RFCGIHFFNP PRYMYLVELI PTPTTRADIL DQLETFITTS
VGKGVVRAKD TPNFIANRVG IAGMLSTMKE AENYGLTYDV VDDLTGKKLG RASSGTFRTA
DVVGLDTMAH VIKTMQDNLA DDPFYPSYAT PPVLARLIEQ GALGQKSGAG FYRKVGKDIL
RFDPAKGDYV PAGAKADEIV SRMLKKAPAE RLKLLRESSN PQAQFLWAIL RNAFHYAAVH
LGEIADSARE VDLAMRWGFG MSQGPFELWQ QAGWKQVAEW VKADIEAGKA LCSAPLPDWV
FDGRDGVHTP EGSWSASQGK YLPRSTLPVY QRQHFPESVY GSGAADPLKA GTEEFRNDEI
RVWTLDGEVL IATITAKLHL ISPTVTEGLM KAVELAEAKY KGLVIWSPDD VFSAGANLEA
LMPVFMAKGS KGIAPEEKKL QDAMLRIRYA QVPVVSAIRG MALGGGCELA IHSARRVAAM
ESYIGLVEVG VGLIPGAGGL TYIARRAAEM AQAGNAGADI LAFLKDGFTS AAMAKVGTSA
LESRKLGYLL DSDVIVPNKD ELLHVALTQA KAMYDSGYRP PHKAVFPVAG RSAKATIVGQ
LVNMRDGGFI SQHDFHLASL IADVVCGGDV EAGSLVNEEY LMGLERKHFC ALLDHPKTQE
RIMGMLQTGK PVRN
//
