ID A0A2S5TH21_9GAMM Unreviewed; 342 AA.
AC A0A2S5TH21;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=C3942_09415 {ECO:0000313|EMBL:PPE74237.1};
OS Solimonas fluminis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Nevskiales; Nevskiaceae;
OC Solimonas.
OX NCBI_TaxID=2086571 {ECO:0000313|EMBL:PPE74237.1, ECO:0000313|Proteomes:UP000238220};
RN [1] {ECO:0000313|EMBL:PPE74237.1, ECO:0000313|Proteomes:UP000238220}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HR-BB {ECO:0000313|EMBL:PPE74237.1,
RC ECO:0000313|Proteomes:UP000238220};
RA Lee Y., Jeon C.O.;
RT "Genome sequencing of Solimonas sp. HR-BB.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPE74237.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; PSNW01000004; PPE74237.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S5TH21; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000238220; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd00659; Topo_IB_C; 1.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:PPE74237.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000238220};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 36..84
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 97..305
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 342 AA; 38413 MW; 47713D51C5B523EA CRC64;
MPRTPLTPEQ LAARAAGLRY VDDAGPGIRR RRLRGGFAYD GPDGRRVRDA ATLERIRRLA
VPPAYTDVWI CADAAGHLQA SGRDARGRKQ YRYHPDWRAV RDADKYGRLL QFGQGLPRLR
RRIAADLRRP GLPREKVLAA VLRLMEKTLI RVGNVEYARS NGSYGLTTLR NRHVEVSGPR
IRFEFRGKSG VRHASSIEDP RLARLLRRCM ELPGQELFQY VDEAGERRPV GSADVNSYLR
QIAGSEFTAK DYRTWAGSVL ALETLRAEAG PPTRARLADM FRQVAKRLGN TPAVCRKCYV
HPAVISSYLE GGLPSPPPGR RPVGEAALLA LLRRRRRSRN PV
//
