ID   A0A2S6C152_9PEZI        Unreviewed;      1007 AA.
AC   A0A2S6C152;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   22-FEB-2023, entry version 14.
DE   RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN   ORFNames=CBER1_00323 {ECO:0000313|EMBL:PPJ53465.1};
OS   Cercospora berteroae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Cercospora.
OX   NCBI_TaxID=357750 {ECO:0000313|EMBL:PPJ53465.1, ECO:0000313|Proteomes:UP000237631};
RN   [1] {ECO:0000313|Proteomes:UP000237631}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS538.71 {ECO:0000313|Proteomes:UP000237631};
RA   de Jonge R., Ebert M.K., Huitt-Roehl C.R., Pal P., Suttle J.C.,
RA   Spanner R.E., Neubauer J.D., Jurick W.M.II., Stott K.A., Secor G.A.,
RA   Thomma B.P.H.J., Van de Peer Y., Townsend C.A., Bolton M.D.;
RT   "Conservation of a gene cluster reveals novel cercosporin biosynthetic
RT   mechanisms and extends production to the genus Colletotrichum.";
RL   bioRxiv 0:0-0(2017).
CC   -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC       (CIA) complex, a multiprotein complex that mediates the incorporation
CC       of iron-sulfur cluster into apoproteins specifically involved in DNA
CC       metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC       adapter between early-acting CIA components and a subset of cellular
CC       target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU367072}.
CC   -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC       {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PPJ53465.1}.
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DR   EMBL; PNEN01000578; PPJ53465.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2S6C152; -.
DR   STRING; 357750.A0A2S6C152; -.
DR   OrthoDB; 38995at2759; -.
DR   Proteomes; UP000237631; Unassembled WGS sequence.
DR   GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR039920; MET18/MMS19.
DR   InterPro; IPR024687; MMS19_C.
DR   InterPro; IPR029240; MMS19_N.
DR   PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR   PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR   Pfam; PF12460; MMS19_C; 1.
DR   Pfam; PF14500; MMS19_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
PE   3: Inferred from homology;
KW   DNA damage {ECO:0000256|RuleBase:RU367072};
KW   DNA repair {ECO:0000256|RuleBase:RU367072};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW   Reference proteome {ECO:0000313|Proteomes:UP000237631};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          40..307
FT                   /note="MMS19 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14500"
FT   DOMAIN          544..955
FT                   /note="MMS19 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12460"
SQ   SEQUENCE   1007 AA;  111906 MW;  87336BB6A505E04A CRC64;
     MSDIQLYLLE VDKNKAEAQT IAAGSAEKLE QKQLKLVKLI TSLEEYINNK DDGALRAKSV
     AYLADVLEKV PPKVFSLQER RLLTDFVLGR IASDLEGIGA SARALLALES LGKWDVETAQ
     KVMRTFVDHT HPLRQFKLQT ERYPIIRLID RLLANYRSGM KSLHEDDPEF MPGFISYFEG
     EKDPRNLMIV FSLLQVPMAE WDIHAYAHDM FDAVFNYFPI TFKPPPDDPY GITAQDLKDR
     LRDCIAANSD FSPYAFPALL DKLDSTSMNT KRDVLHTLQA CAVSYSANTV NLYSVTLWDA
     LKFEIINVQE EDLAEEALKA LALIAAKLAP IDNALSAYLK PIVKECNEHL EDAPTKQSQG
     AGRIILAVAR TNPIVADKVT KGILPVLFSL YGSSTSIAKR RGLLEVYSSL VQAHADLQAS
     GHEVSVEGLQ AFLDQAMTAM LHALARAPKP EVSFRLTAMN GLIQLISARK VLSPEQLGLA
     VSAVHDVVLH EQIEGHGNIR SEAIAALVEI AAAAPDAIRD QTVPAFMVEL PDDAQDRATY
     RSALEAFAQL SHEQQIFDTV VLRLKNKLKA AQSRPESKEL ELDLLLAILY CFTNGSPMKE
     ESAGIRGDYY TDYAEYMIQR LRDTSALDVE TSTAAIVGRL TNHILRQQTP HFQATVYNKD
     LEWLSPAKAS GPDDATKRVR DYAPFALYYY AAVRPEIIDP QDIMTTLQTQ AALLLNGEPD
     LVVRASVIRH LSLLINKFLE PKTLESSLQL GGIDVEALLS DHTNTTKSSI SFAVLRAMMV
     QGKCGALTSR YIEALLRTLP EANKAFARNF VLLLSPDDIL SKENHCIISG LYKQRAFSQL
     VKPINDRVRA AEASAKTNYL IAMSGILQWL PYSVIESSLG DLMPALLQCM DLKDAGDQNV
     KYSTLVIFES VLMHDPAIVA EHARSLINRL LDATHGSPNE AKVRAKALRC LTLVPKQLKR
     EAVIPYRRPV VKKLLSCLDD GKRNVRMEAV RCRSAWLALD EGTEEEE
//