ID A0A2S6CA17_9PEZI Unreviewed; 466 AA.
AC A0A2S6CA17;
DT 18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT 18-JUL-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Probable kinetochore protein NUF2 {ECO:0000256|ARBA:ARBA00017594};
GN ORFNames=CBER1_01840 {ECO:0000313|EMBL:PPJ56579.1};
OS Cercospora berteroae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Cercospora.
OX NCBI_TaxID=357750 {ECO:0000313|EMBL:PPJ56579.1, ECO:0000313|Proteomes:UP000237631};
RN [1] {ECO:0000313|Proteomes:UP000237631}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS538.71 {ECO:0000313|Proteomes:UP000237631};
RA de Jonge R., Ebert M.K., Huitt-Roehl C.R., Pal P., Suttle J.C.,
RA Spanner R.E., Neubauer J.D., Jurick W.M.II., Stott K.A., Secor G.A.,
RA Thomma B.P.H.J., Van de Peer Y., Townsend C.A., Bolton M.D.;
RT "Conservation of a gene cluster reveals novel cercosporin biosynthetic
RT mechanisms and extends production to the genus Colletotrichum.";
RL bioRxiv 0:0-0(2017).
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|ARBA:ARBA00002772}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NUF2 family.
CC {ECO:0000256|ARBA:ARBA00005498}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PPJ56579.1}.
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DR EMBL; PNEN01000515; PPJ56579.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2S6CA17; -.
DR STRING; 357750.A0A2S6CA17; -.
DR OrthoDB; 7316at2759; -.
DR Proteomes; UP000237631; Unassembled WGS sequence.
DR GO; GO:0031262; C:Ndc80 complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.10.418.60; Ncd80 complex, Nuf2 subunit; 1.
DR InterPro; IPR005549; Kinetochore_Nuf2_N.
DR InterPro; IPR041112; Nuf2_DHR10-like.
DR InterPro; IPR038275; Nuf2_N_sf.
DR PANTHER; PTHR21650:SF2; KINETOCHORE PROTEIN NUF2; 1.
DR PANTHER; PTHR21650; MEMBRALIN/KINETOCHORE PROTEIN NUF2; 1.
DR Pfam; PF03800; Nuf2; 1.
DR Pfam; PF18595; Nuf2_DHR10-like; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000237631}.
FT DOMAIN 31..170
FT /note="Kinetochore protein Nuf2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03800"
FT DOMAIN 284..400
FT /note="Nuf2 DHR10-like"
FT /evidence="ECO:0000259|Pfam:PF18595"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 335..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 178..243
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 466 AA; 54669 MW; 6BEAE0DC87545AFD CRC64;
MPSMDYNPRM SMAGGRTVSS QQKKQKEPDE DAFMTLPDKE IAGCISDIGI SFTLEDLRKP
NPQQIQKVFE WFAELLTNTT REVVAPAMRA AAEDMCGDDS ERIFTADTRE LMGFFIVMRK
LLLECGIKDF TFSDIYRPTH PRLVKIFSYI INFIRFRESQ TNVIDEHYNS SGRTKNTIEQ
LYHANQDKED QLHEMQQNRK NVEAALQQKE QRSTELKTRL LELKKAQERV TEKLERVKGE
QSRLKSLLED KTTSVMQTRA EAAKLRPYTE QSPAHLEQSL RDLSSNLASD RNEIERLDKR
ARTLQTSCDT FSLLQTDISS LTRLLSDLDQ ELQKEEEEQR AAAKNRDALT EKSNNVREVE
RQEKMLRKQL QQWQDRTEKL RKDAETRAQN AKGKMEALRA THRELTAERR ERGEEVEKRR
VRIEQTEKKM ADLKEQIEHE VQAAREEYMK MESHIRLYIT EMEQNL
//
